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2013-2014, ősz (AOVHUM084_1A)



Introduction to the underlying molecular mechanisms of human development and malformations. Revealing examples of environmental effects on pregnancy. Studying the formation of normal adult anatomy.

Main topics:
  • Introduction to developmental biology and its substantiality in medicine
  • Tools of experimental embryology
  • Regulatory mechanisms of ontogenesis: maternal effect, polarisation, homeobox genes, transcription factors, epigenetic effects, role of extracellular factors (growth factors, extracellular matrix, basal membrane) in cellular differentiation, cell migration
  • Stem cell biology and regeneration
  • Germline determination, oogenesis
  • Teratogenesis
  • Axis formation


1 Introduction to developmental biology and its significance in medical curriculum (Imre Oláh) 2013.09.12.
2 Experiments in developmental biology (Nándor Nagy) 2013.09.19.
3 Regulatory mechanisms of ontogenesis I. (Krisztina Herberth-Minkó) 2013.09.26. letöltés
4 Regulatory mechanisms of ontogenesis II. (Krisztina Herberth-Minkó) 2013.10.03. letöltés
5 Regulatory mechanism in development III. (Krisztina Herberth-Minkó) 2013.10.10. letöltés
6 Stem cells (Nándor Nagy) 2013.10.17. letöltés
7 ECM role in the development. (Katalin Kocsis) 2013.11.14. letöltés
8 Germ cell determinants and oogenesis. (Katalin Kocsis) 2013.11.28. letöltés
9 The embryonic origins of left-right asymmetry (Nándor Nagy) 2013.12.05. letöltés


Tematika, órarend (2013-2014)

Topic list – Developmental Biology I 2017.05.03.

Topics of the exam

Developmental Biology I. course

2013/2014. year 1st semester

Topics of the exam

1. Stem cell biology, types of stem cells. Induced pluripotent stem cells.

2. Teratogenesis. Developmental biological aspects of Contergan catastrophe.

3. Developmental biology experiments.

4. Genetic hierarchy of early developmental events from Drosophila to mammals (maternal-effect genes, gap genes, pair-rule genes, segment-polarity genes, homeotic genes).

5. Regulatory mechanisms of ontogenesis II: growth and transcription factors.

6. Regulatory mechanisms of ontogenesis III.: epigenetic influences on gene expression: DNA metilation, X chromosome inactivation, genetic imprinting; hydatidiform mole.

7. Ephrin-Ephrin receptor in the developmental biology.

8. Notch signaling and its biological role.

9. ECM, basal lamina-cell migration, epithelial morphogenesis and branching.

10. Germ line determinants, oogenesis.

11. Axis formation.