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Neurotransmission and neuromodulation research group

Members:
Klara Gyires, M.D., Ph.D., D.Sc., professor, leader of the group
Laszlo G. Harsing, M.D., Ph.D., D.Sc., senior research associate
Laszlo Köles, M.D., Ph.D., associate professor
Mahmoud Al-Khrasani, Ph.D., assistant professor
Zoltán Zádori, M.D., Ph.D., assistant professor
Erzsébet Kató, M.D., Ph.D., assistant professor
Bernadette Lázár, Ph.D. student
Viktória Humli, Ph.D. student
Judit Szepesy, Ph.D. student
Eszter Berekméri, PhD student

Balogh Mihály, M.D.,  Ph.D. student
Veronika Pol-Maruzs, laboratory assistant

Projects

•  Centrally induced gastroprotective action of substance P (SP)
•  Glycine transporter type 1 (GlyT-1) – potential therapeutic target in retinal neurodegenerative disorders
•  Imidazoline receptors are not involved in the regulation of gastric motility
  Hearing and deafness: molecular mechanisms and therapeutic approaches

Experimental Methods

•    In vivo ulcer models
•    Measurement of gastrointestinal motility in vivo and in vitro
•    Acute and chronic inflammatory models
•    Measurement of microcirculation with Laser Doppler flowmetry
•    Stereotaxic injection into given brain nuclei
•    Genotyping of KO-mice with PCR
•    Patch clamp method
•    Brain microdialysis in anesthetised and conscious rats. Measurements of biogenic amines and amino acids with HPLC and electrochemistry.
•    Measurements of radiolabelled neurotransmitter release from isolated brain slices and retina preparation using superfusion techniques.
•   Functional imaging (Ca2+, ROS, mitochondrial membrane potential)
•   Objective audiometry on mice and rats (ABR)
•   Hearing loss models (aminoglycoside- and noise-induced hearing loss)

 Main cooperators

•     Department of Organic Chemistry, Semmelweis University
•     Department of Pharmacodynamics, Semmelweis University
•     Department of Pharmacology and Pharmacotherapy, University of Debrecen
•     Albert-Ludwigs University of Freiburg, Ins. of Experimental and Clinical Pharmacology and Toxicology , Freiburg, Germany
•     Karl-Franzens University of Graz, Dept. of Experimental and Clinical Pharmacology, Graz, Austria
•     Medical Faculty of Parma, Dept. of Pharmacology, Parma, Italy
•     University of Leipzig, Rudolph-Boehm Institute of Pharmacology and Toxicology, Leipzig, Germany
•     University of Coimbra, Center for Neuroscience, Coimbra, Portugal