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Neuropsychopharmacology research group

Members:
Pál Riba, M.D., Ph.D., associate professor, group leader
Joseph Knoll, emeritus professor, Ordinary member of the Hungarian  Academy of Sciences
Susanna Fürst, emeritus professor
Júlia Tímár, M.D., Ph.D., associate professor, deputy head of department
Ildikó Miklya, Pharm.D., Ph.D., associate professor
Laszlo Köles, M.D., Ph.D., associate professor
Mahmoud Al-Khrasani, Pharm.D., Ph.D., assistant professor
Zsuzsanna Gyarmati, Pharm.D., consultant
Kornél Király, M.D., Ph.D., assistant professor
István Gyertyán MD guest researcher
Ferenc Kassai  guest researcher
Aliz Ernyeiguest researcher
Imola Plangár, guest researcher
Apolka Szentirmay, M.D., Ph.D. student

Mihály Balogh, M.D., Ph.D. student

 

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Projects

Looking for new ways for analgesia

Establishment of a cognitive test battery with high translational value

 Experimental Methods

•   Measurement of the electrophysiological parameters of receptor pool and receptor kinetics of in vitro isolated organs.
•   Immunohistochemistry
•   In vivo antinociceptive tests, tolerance-dependence measurments, intracerebral, spinal application methods
Electrochemical HPLC measurement of transmitter release in isolated organs (rabbit ear artery, rabbit pulmonary artery, rat vas deferens, etc) and to detect specific enhancer effect in isolated brain regions (tuberculum olfactorium, substantia nigra, striatum, raphe, locus coeruleus).
•   Measuring enhancer activity on cell cultures (PC12, HBEC) and stroke models
•   Measuring general, hypo- and hyper-locomotor activity
•   Studying cognitive functions, learning and memory, – active (shuttle-box) and passive learning tests, recognition of new object (NOR)
•   Studying anxiety and anxiolytic effect – elevated plus maze test (EPM), conditioned place aversion (CPA)
•   Studying the development of dependence – physical dependence and conditioned place preference (CPP)
•   Studying maternal behavior – observation and pup retrieval test
•   Applying depression models – learned helplessness, bilateral bulbectomy
•   Studying the sensitivity of postsynaptic receptors – dopamin-induced stereotyped behavior, serotonin-syndrome
•   Measuring transmitter release from in vitro tissue preparations (GABA, endomorphine 2, CGRP, [3H]-norepinephrine, dopamine, serotonin) by radioactive isotope and immunological technics