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Faculty of Medicine
2 credit points, practical mark, Miklós Csala; AOVOVM414_1A

2018/2019 Spring semester

Teaching secretary: Prof. Miklós Csala


The single semester course of this elective subject consists of weekly lectures. Students must attend at least 75% of the lectures, i.e. they cannot have more than 3 absences to achieve the signature.

The practical mark is based on the result of a written test at the end of the semester. The questions regard the material of the lectures, and they can be answered in a few words.

Introduction of the subject

Thorough understanding of the molecular mechanisms that underlie the diseases is indispensable for a high level and effective medical profession. While the subjects of biochemistry and molecular cell biology include the metabolism, the fundamental molecular biology and regulation of healthy cells, tissues and organisms, pathobiochemistry deals with malfunctions and derangement of these processes and systems in certain human diseases. Besides typical disorders of various subcellular organelles and of the extracellular matrix, the students will get acquainted with the genetic backgrounds and molecular mechanisms of pathological conditions such as obesity, diabetes mellitus, malignant tumors, neurodegenerative diseases, hemostatic abnormalities or alcoholic liver damage. Pathobiochemistry – in contrast to the clinical subjects – does not serve by teaching the symptoms, (differential) diagnosis or therapeutic possibilities of selected illnesses but it helps learn the up-to-date scientific explanations of them. Therefore, the course describes the biochemical and cell biological basis of some particularly important diseases in more detail compared to the compulsory subjects, yet it also aims to form and reinforce a molecular approach of medicine in the students.

The Hungarian course of the subject was reformed in 2014, and it has been receiving a positive feed-back since then. Anonymous evaluations revealed clearly that the attendants find the course highly useful – even to acquire learning the compulsory subjects.


Location: EOK (Tűzoltó u. 37-47.) Békésy György Lecture Hall

Duration: 2 x 45 min (Fridays 14:30-16:00)

8 FebIntroduction to PathobiochemistryCsala
15 FebOxidative stress and antioxidant defenseSzelényi
22 FebAlcoholic liver diseaseCsala
1 MarHyperammonemiaCsala
8 MarDisorders of amino acid metabolismLizák
15 Mar--- National holiday ---
22 MarObesityRónai
29 MarInsulin resistance - the metabolic syndromeCsala
5 AprDiabates mellitusCsala
12 AprAtherosclerosisMüllner
19 Apr--- Good Friday ---
26 AprThe molecular background of cancer ICsala
3 MayThe molecular background of cancer IICsala
10 MayAmyloidosis and prion diseasesMészáros, T
17 MayWritten test-


Students will demonstrate their knowledge by answering about a dozen of short questions in writing. This test will take about 15 minutes in the last week of the semester (see the lectures’ schedule). The expected answers will be a few words each, and they will have been presented within the lectures throughout the course.

The grade of the written test is also the practical mark to be recorded in Neptun. The test cannot be retaken; there will be one opportunity for all students to write it.


Lecture slides and handouts are available here.

The password to download pages can be obtained from the lecturers of the course personally.