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School of Ph.D. Studies

7. MOLECULAR MEDICINE
Chairman:
József MANDL M.D., member of the Hungarian Academy of Sciences
Centre of Theoretical Medicine
37-47 Tűzoltó u. Budapest H-1094
Hungary
Tel/Fax: +36 1 266 2755
E-mail: molorv@eok.sote.hu, jozsef.mandl@eok.sote.hu

General Overview: The postgraduate school of molecular medical sciences serves for both biomedical basic research and primary training of researchers starting their careers in the fields of clinical research. One of the major drawbacks of biomedical research is that there is no efficient connection between the basic and clinical research. Therefore, five main Programs involve applied theoretical knowledge together with clinical research.


PROGRAM 7/1. CELLULAR AND MOLECULAR PHYSIOLOGY
Coordinator:
Erzsébet LIGETI M.D., member of the Hungarian Academy of Sciences
Department of Physiology
37-47 Tűzoltó u. Budapest H-1094
Tel: +36 1 266 9180 ext 60457; +36 1 266 6504
Fax: +36 1 266 6504
E-mail: erzsebet.ligeti@eok.sote.hu

Program Overview: The Program provides opportunity to receive training in the field of physiology. The professors of the Program offer courses and individual training for the Ph.D. students on their respective scientific research areas. Training courses include continuous basic methodical and scientific training for small groups of students. Individual training focuses on research under the supervision of training advisors aimed at understanding physiological regulatory mechanisms at the cellular level using electrophysiological, molecular biological, biochemical, cell biological and physiological methods.

Titles of research projects Supervisors
Investigation of two-pore domain potassium channels. Gábor CZIRJÁK
Investigation of the structure-function relationship of TrpM2 cation channels László CSANÁDY
Receptor mediated regulation of 2P type potassium channels. Péter ENYEDI
Charge compensation mechanisms of reactive oxygen species forming enzymes Miklós GEISZT
Investigation of reactive oxygen producing enzymes in mammalian cells Miklós GEISZT
Molecular bases of angiotensin receptor function László HUNYADY
Regulation of G protein-coupled receptors László HUNYADY
Molecular basis of regulation of circadian rhythm Krisztina KÁLDI
Role and regulation of Rho family GTPase activating proteins (GAPs) Erzsébet LIGETI
Role of NADPH oxidase in antibacterial defense Erzsébet LIGETI
Cellular and molecular biological processes of neuron formation by various neural stem cells Emília MADARÁSZ
Neural Cell Differentiation Emília MADARÁSZ
Effects of nanoparticles on neural tissue cells Emília MADARÁSZ
Investigation of proteins involved in the differentiation and function of osteoclasts Attila MÓCSAI
Molecular mechanism of bone metabolism Attila MÓCSAI
Analysis of phagocytic cells of the immune system Attila MÓCSAI
The role of ion channels in supporting the function of NADPH Gábor László PETHEŐ
Interaction between cytosolic and mitochondrial Ca2+ signalling András SPÄT
The molecular and physiological role of inositol lipids Péter VÁRNAI

PROGRAM 7/2. Pathobiochemistry
Coordinator:
József MANDL M.D., member of the Hungarian Academy of Sciences
Department of Medical Chemistry,
Molecular Biology and Pathobiochemistry
37-47 Tűzoltó u. Budapest H-1094
Tel/Fax: +36 1 266 2755
E-mail: mandl.jozsef@med.semmelweis-univ.hu

Program Overview: Pathobiochemistry showed a remarkably dynamic progress in the past decades. The Program has two roles: a.) it outlines the etiology and pathogenesis of different pathological conditions, b.) it aims to help the detailed knowledge of certain important fields of pathology. In planning the program the following viewpoints were considered: in diseases different mechanisms of pathological regulation can develop, reflecting changes in extracellular signals or signal transduction.
 

Titles of research projects Supervisors
The comparative examination of gene polymorphisms vascularis in clinical pictures György ACSÁDI
Investigation of differentiation processes in human stem cells Ágota APÁTI
Study of genetic variation in the development of drug      addiction and other psychiatric disorders Csaba BARTA
Transport systems in the endoplasmic reticulum Gábor BÁNHEGYI
Neuronal scafford proteins László BUDAY
Investigation of signalling pathways of receptor tyrosine kinases László BUDAY
Redox metabolism in the endoplasmic reticulum Miklós CSALA
Analysis of learning and memory using experimental a network approaches Péter CSERMELY Csaba SŐTI
Characteristics of calcium transporters Ágnes ENYEDI
Genetical and immunological factors in rheumathological conditions Pál GÉHER
High performance proteomic methods in biomarker discovery András GUTTMAN
Application of the specialities of separation techniques in QSAR studies Miklós IDEI
The genetic background of gynaecological clinical pictures József Gábor JOÓ
Association of estrogen receptor gene polymorphisms with serum lipoprotein levels and hemostatic factors István KARÁDI
Patobiochemistry of rare metabolic disorders Tamás KARDON
Rational drug design of kinase inhibitor agents György KÉRI
Cellular signalling therapy with kinase inhibitors György KÉRI
Study of transporter-drug interactions in human and rat hepatocytes Katalin JEMNITZ
The role of endoplasmic reticulum in lipid metabolism.the road to diabetes Éva KERESZTURI
Genetic and epigenetic factors in the background of sudden cardiac death Gergely KESZLER
Cell dependent thrombolysis Krasimir KOLEV
The role of pathobiochemical factors in the development and progression of inflammatory bowel diseases Péter László LAKATOS
Endoplasmic reticulum stress József MANDL
Human diseases caused by mutations in endoplasmic reticulum proteins Éva MARGITTAI
Determination of hydrophobicity of the new selective tyrosine kinase inhibitor molecules. Modelling the relationship between structure and biological activity György MÉSZÁROS
Selection and application of protein specific aptamers Tamás MÉSZÁROS
Genetic polymorphisms in monoamine neurotransmitter systems: association analyses and functional study Zsófia NEMODA
Gene x environment interactions in psychiatric genetics: analyzing DNA methylation level Zsófia NEMODA
Design, synthesis and structure- biological activity correlation studies of anticancer and antimicrobial agents László ŐRFI
Molecular pharmacology of the signal transmission therapies affecting the regulation of cell death following molecular farmacodiagnostics István PETÁK
Analysis of small and large-scale copy number variations Zsolt RÓNAI
Pathobiochemistry of pancreatic digestive enzymes Miklós SAHIN-TÓTH
Membrane transporter proteins of human stem cells and their changes during cell differentiation Balázs SARKADI
Association between the structure and function of human ABC transporter proteins Balázs SARKADI
Studies on ABC transporters in malignant tumors Balázs SARKADI
Genetical risk factors in complex hereditary diseases Mária SASVÁRI
Cross-talk between signaling pathways regulating proliferation, differentiation and cell death of B-lymphocytes Gabriella SÁRMAY
The role of protein denaturation and stress response in aging Csaba SŐTI
Stress responses in aging Csaba SŐTI
Research and development of molecules targeting multidrug resistant cancer cells Gergely SZAKÁCS
Simultaneous application of quantitative molecular genetic measurements and high capacity cell sorting in malignant disorders of the myeloid system Attila TORDAI
Changes of the placental function in preeclampsia Sándor VALENT
Characterization of ABCG-type transporters András VÁRADI
The role of the human ABCC6 in arterial calcification András VÁRADI
The role of Na-K ATPase in the pathomechanism of diabetes mellitus Ágota VÉR
The prevention of the diabetogenic side effects of antipsychotics László VÍGH
UV-induced tumorigenesis in skin: molecular biological mechanisms, its regulation and pathobiochemical events Norbert WIKONKÁL

PROGRAM 7/3. Embryology, Theoretical, Experimental and Clinical Developmental Biology
Coordinator:
Ágoston SZÉL M.D., Ph.D., D.Sc.
Department of Human Morphology and Developmental Biology
58. Tűzoltó u, Budapest H-1094
Tel: +36 1 218 2101; fax: +36 1 215 3064
E-mail: szel@ana2.sote.hu

Program Overview: The program deals with the progressive changes of the vertebrate organisms from the primordial germ cells through the fertilization up to the organogenesis. During this progressive development primary tissues (epithelial, supporting, muscle and nervous tissues) are formed from different stem cells or progenitors, what is timely and spatially strictly regulated at both genetic and molecular levels. The Program focuses on the early formation of lymphoid organs including the epithelio-mesenchymal interactions (thymus and bursa of Fabricii), formation of hemopoetic sites, cardiac anlage, accessory dendritic cells of the immune system and the effect of different environmental agents on the ontogeny. The ontogeny of the visual system and its relationship with the circadian rhytms (pineal body) is a significant and progressive topic of the Program. The endocytosis by the monocyte-macrophage system is also a rapidly expanding area of the Program. Finally, characterization of the accessory cells of the MALT in avian species and human completes the series of scientific topics. The methods used by the Program incorporate a wide range of different techniques like light- and electron microscopy, immunocytochemistry, immunofluorescence combined with confocal microscopy, monoclonal antibody production, tissue culture, embryo manipulation (ablation and transplantation of embryonic organ rudiments, chimaerism, parabiosis) and Western blotting.

Titles of research projects Coordinators
Role of caveolae and caveolin isoforms in various function of the cells Anna L. KISS
In vitro organotypic retinal cultures to study cone differentiation in mammals Ákos LUKÁTS
Developmental biology of the hemopoietic organs Nándor NAGY
Development of lympho-myeloid organs and supporting tissue Imre OLÁH
Photosensitive molecules and photoreceptors in the vertebrate retina and pineal gland Ágoston SZÉL

PROGRAM 7/4. Basis of Human Molecular Genetics and Gene Diagnostics
Coordinator:
András FALUS M.Sc. member of the Hungarian Academy of Sciences
Department of Genetics, Cell- and Immunobiology
4. Nagyvárad tér, Budapest H-1089
Tel: +36 1 210 2930 ext 6241;
Fax: +36 1 303 6968
E-mail: faland@dgci.sote.hu

Program Overview: To provide an overview on various fields of human medical and molecular genetics, genomics, including theory and methodology.

Title of the research project Coordinators
Molecular studies in blood coagulation Imre BODÓ
Studies on the pathomechanism of rheumatology diseases Imre BODÓ
Studies on the development of diseases with immunepathomechanism Edit BUZÁS
Studies on extracellular vesicles Edit BUZÁS
Molecular biological methods in examining patients with muscular dystrophies Veronika KARCAGI
Application of aCGH in molecular cytogenetics for identification of different syndromes Veronika KARCAGI
Chemotaxis – Its biological and clinical significance László KŐHIDAI
Impedimetry – Its applications in different fields of cell biology László KŐHIDAI
The introduction of systems biology int he research of the diagnosis, prevention and therapy of neurological and psychiatric disorders Mária Judit MOLNÁR
Genetical and immunological factors in rheumatological conditions György NAGY
Pál GÉHER
Investigation of the mechanism of immune tolerance during pregnancy Éva PÁLLINGER
Laboratory analyzes of complex oncohematological diseases Éva PÁLLINGER
Study on the pathomechanism of asthma with molecular genetic methods Csaba SZALAI
Evaluation of medical biology data Csaba SZALAI
ALL genomics Csaba SZALAI
Simple nucleotid polymorphisms in the development of paradontal disease and missing tooth-germs Gábor VARGA
Isolation and characterization of dental postnatal stem cells Gábor VARGA
Regulation of epithelial cell proliferation and gene expression Gábor VARGA
The role of the human ABCC6 in arterial calcification András VÁRADI
Prognostic significance of the clinical parameters and cytochin polymorphism results in multiple myeloma and myelodysplasia Judit VÁRKONYI

PROGRAM 7/5. IMMUNOLOGY
Coordinator:
Gyula POOR M.D., Ph.D., D.Sc.
Institute of Rheumatology and Physiotherapy,
Frankel Leo u.25-29, Budapest H-1023,Hungary
Tel: +36 1 4388314
Fax: +36 1 212 2676
E-mail: poor.gyula@orfi.hu

General overview: The recognition of immunology as an independent scientific discipline is recent, therefore, in many universities immunological research is carried out in various (e.g. biochemical etc) departments. Qualified immunologists are greatly demanded in many areas, including clinical science. This project, completing the curriculum of undergraduate training, yields a perspective to qualify in several areas of immunology. The purpose of this Ph.D. Program is to train independent, reliable and competent research scientists. The Program emphasizes the importance of studying basic immunology and laboratory methods, both being prerequisites of any work in experimental and clinical immunology.

Title of research projects Supervisors
Regulation of immune reactions and role of cytokines in the pathomechanism of autoimmune diseases. Péter GERGELY
Acute phase proteins in clinical diagnostic László KALABAY
Analysis of pathogenesis, clinical and laboratory characteristics of systemic autoimmune diseases Emese KISS
Expression of proto-oncogenes and tumor suppressor genes in gestational trophoblastic tumors and normal pregnancy Vilmos FÜLÖP
László KOPPER
The effects of immunological and environmental factors in various inflammatory and/or malignant cellular proliferations Beatrix KOTLÁN
Study of calcium transport systems in various cancer cells Tünde KOVÁCS
Signal transduction and membrane transport process in the immune system Erzsébet LIGETI
Balázs SARKADI
The role of neuroimmunological and neuro-osteoimmunological mechanisms in rheumatic diseases Péter MANDL
Effect of bacterial product of progression of HIV infection Károly NAGY
Infection and autoimmunity in inflammatory diseases Gyula POÓR
Investigation of molecular mechanisms in rheumatic, immunological and bone disorder Gyula POÓR