Dean of the Faculty of Medicine

Dr. Miklós Sándor Zoltán Kellermayer
Faculty of Medicine, Dean

Date and place of birth:
Pécs, 17th June 1964

Marital status:
married, father of 5 children

Studies:
1988, Doctor of Medicine (No. 69-66/1988), University of Pécs, Medical School
1998, Ph.D., Medicine (No. 117-3/1998), University of Pécs, Medical School
2008, D. Sc., Hungarian Academy of Sciences (MTA)
2004, Habilitation, University of Pécs, School of Medicine

Professional experience:

Research interests:

1. Development and applications of single molecule methods. Single molecule manipulation with laser tweezers and atomic force microscopy. Space- and time-synchronized single molecule mechanical and fluorescence measurements. Combination of total internal reflection fluorescence and AFM. Development and adaptation of force-feedback laser tweezers for biomolecular systems.
2. Mechanisms of motor protein function, muscle contraction and contraction regulation. Investigation of actomyosin interaction by in vitro motility test. AFM morphology and mechanical stability of myosin molecules and thick filaments.
3. Nanomechanics of biopolymers. Molecular biophysics of cytoskeletal and extracellular filamentous proteins. Molecular biophysics of titin giant muscle protein. Domain-level regulation of titin flexibility and stability. Mechanosensory mechanisms in titanium. Nanomechanics of the desmin intermediate filament. In situ and in vitro elasticity of collagen. Molecular mechanisms of fibrin polymerization and elasticity. Molecular mechanics of DNA, RNA and their protein complexes. Nanomechanics of desmin intermediate filaments.
4. Nanobiology of amyloid fibrils. Structure of beta amyloid and systemic amyloid fibrils. Mechanical manipulation of individual amyloid fibrils. Molecular mechanisms of transthyretin amyloid fibrillohenesis.
5. Nanobiotechnology. Synthesis of specific biomolecular handles. Investigation and application of oriented, self-assembling amyloid nanostructures, nanolectronics.
6. Imaging and nanomanipulation in in vivo systems. Nanoparticle based in vivo imaging. Dynamic tracking of muscle structure in vivo by multiphoton microscopy.
7. High-resolution structure, mechanical properties, and DNA ejection mechanisms of viruses.Measurement of viral (T7) capsid structure and nanomechanics with AFM, tracking of mechanically controlled DNA ejection, complex high-resolution structure and interactions of the tail.
   
8. Structure and nanomechanics of membrane systems. Mechanical manipulation of liposomes and cochlates by AFM. Biodistribution of liposome and cochleate particles.

Awards, fellowships:

1. 1981 National Honor Society of the USA Award in Chemistry
2. 1984 Histology competition, 1st prize, University of Pécs, Medical School
3. 1984 1988 Hungarian State Scholarship
4. 1985 National Student Research Conference, Budapest, 1st prize
5. 1987 National Student Research Conference, Pécs, 1st prize
6. 1988 Rector’s award for thesis, 1st prize, University of Pécs, Medical School
7. 1988 Graduation with award: Summa cum laude
8. 1988 “Verzár Frigyes” Award of the Hungarian Biological Association
9. 1988-1989 Postdoctoral Research Fellowship of the Hungarian Academy of Sciences
10. 1991-1993 American Heart Association, Washington Affiliate, Postdoctoral Research Fellowship
11. 1994 American Biophysical Society Travel Fellowship
12. 1998 “Kovács Tibor” Award, Hungarian Immunological Society
13. 1998 “Magyary Zoltán” Postdoctoral Fellowship, Foundation for Hungarian Higher Education and Research
14. 1998-2001 “Bolyai János” Postdoctoral Fellowship, Hungarian Academy of Sciences
15. 1999 American Biophysical Society Travel Fellowship
16. 2001-2005 HHMI International Research Scholarship
17. 2001 Hungarian State Eötvös Fellowship
18. 2003-2005 Széchenyi Fellowship
19. 2005 Best Lecture Award, Regional Committee of the Hungarian Academy of Sciences
20. 2006 University of Pécs Publication Prize
21. 2009 Sanofi-Aventis/Chinoin Research Prize in Nanotechnology
22. 2013 “Huzella Tivadar” Award for research achievements, Semmelweis University
23. 2016 “Kerpel-Fronius Ödön” Award for contributions in the talent support program, Semmelweis University
24. 2017 Merit Award for best lecturer, Semmelweis University, Faculty of Medicine
25. 2018 Merit Award, Semmelweis University, Faculty of Medicine
26. 2018 Outstanding PhD mentor, Semmelweis University
27. 2019 Publication Award, Semmelweis University
28. 2019 Merit Award, Semmelweis University, Faculty of Medicine
29. 2020 Merit Award, Semmelweis University, Faculty of Medicine
30. 2021 Merit Award, Semmelweis University, Faculty of Medicine
31. 2022 Merit Award, Semmelweis University, Faculty of Medicine
32. 2022 Hungarian Order of Merit Officer’s Cross
33. 2023 Merit Award, Semmelweis University, Faculty of Medicine

Memberships:

1. Hungarian Microscopical Society (since 1989)
2. European Society for Microscopy (since 1989)
3. American Biophysical Society (since 1991)
4. American Association for the Advancement of Science (since 1995)
5. Hungarian Biophysical Society (since 1998)
6. Hungarian Biochemical Society (since 2001)
7. New York Academy of Sciences (since 2004)
8. European Society for Muscle Research (since 1994)
9. American Society for Biochemistry and Molecular Biology (since 2005)
10. Academia Europaea (since 2019)
11. Szent István Academy of Sciences (from 2022)

Prior grant support:

1. FEFA Project No. 3313, Sub-project No. 687-6.2, 1994.
2. Health Scientific Council T-06 622/93. ““Investigation of the pathomechanism of myocardial ischemia in a molecular model system”. 1993-1996, principal investigator.
3. Youth OTKA instrument competition supported by a World Bank loan W015117, 1995, Principal investigator.
4. Youth OTKA F 017164. “Structural and functional reconstruction of myofilaments of striated muscle”. 1995-98, Principal investigator.
5. Higher Education Program Financing Application. PFP-1013/98. Promoting talent support in higher education: “Interactive teaching of molecular biophysics”. 1998, project leader.
6. NATO grant for organizing NATO Advanced Research Workshop: Biological, Biophysical and Theoretical Aspects of Polymer Structure and Transport, Bikal, Hungary, June 15-20, 1999. (Co-Director).
7. OMFB Patronage Application. OMFB 01871/98. Travel allowance for the 1999 Congress of the American Biophysical Society Congress
8. OMFB Patronage Application. OMFB-02248/98. Support for conference organization. “Polymer structure and transport…/Bikal 1999 jún 20-25/”.
9. Health Scientific Council T-06 021/97. “In vitro investigation of the mechanism of action of calcium-sensitizing drugs in dynamic molecular model system on biopsy samples from cardiomyopathic patients” 1997-1999. Principal investigator.
10. OTKA F 025353. “Molecular biophysics of the giant protein titin”. 1998-2001. Principal investigator.
11. OTKA T25206. “Interactions between molecular chaperones (nurse proteins) and the cytoskeleton” 1988-2001. (Principal investigator Dr. Péter Csermely).
12. KMÜFA Műszer-2 MU-00550/2000. “Upgrading the molecular force laser tweezer device.” Principal investigator.
13. OTKA T032700. „Dynamic and conformational properties of contractile protein molecules ” 2000-2003. (Principal investigator Dr. Béla Somogyi )
14. European Community 5th Framework Program. Muscle and Motility Research Training Network Grant. RTN1-1999-00419. Project leader of the research group at PTE.
15. Howard Hughes Medical Institutes International Research Scholar Grant 55000314. “Molecular Biophysics of the Muscle Cytoskeleton” 2001-2005. Principal investigator.
16. OM KKK 0004/2000, PTE – South Transdanubia Cooperative Research Center. Analytical application of lasers department. Head of the Nanobiotechnology unit.
17. OTKA T037935. “Molecular mechanics of cytoskeletal muscle proteins by nanobiotechnological methods”.2002-2005. Principal investigator.
18. OM Biotechnológia BIO-110/2002. “Development of specific nanocips for manipulation of single biomolecules ”2003-2005. project head.
19. ETT 440/2003. “Nanomechanics of collagen” 2003-2005. Principal investigator.
20. Apponyi Patronage. Organisation of the Nanobiology Conference 2006. 500K HUF. Principal investigator.
21. OTKA T049591 “Nanomechanics of Amiloid ß-fibrils” 2005-2008. 19.500K HUF. Principal investigator.
22. OTKA TS049812 “Structural foundations of protein-protein interactions and their biological role: a multidisciplinary approach” 2005-2007. 90,000K HUF. Principal investigator: Dr. László Gráf.
23. Portuguese-Hungarian TéT. Port-19/2005. TTR-Amyloid Fibrils. 2006-2007. 1,630K HUF. Principal investigator.
24. Öveges HEF_06_1-NANOBTEC. Research and education of Nanobiotechnology. 2006-2007. 1,800K HUF. Principal investigator.
25. Öveges HEF_06_2-TITINMEC.Mechanisms of the titin giant protein mechanosensor. 2006-2007. 9,900K HUF. Principal investigator.
26. Öveges HEF_06_3-FILBIONA. Nanomechanical investigation of filamentous biomolecular systems.2006-2007. 5,400K HUF. Principal investigator.
27. ETT-506/2006. The role of cytoskeletal filaments in the pathological mechanical rearrangement of striated muscle. 2006-2008. 2,700K HUF. Principal investigator.
28. OTKA Publication Application P050134. Spatially and temporally synchronized atomic force and toral internal reflection fluroescence microscopy for imaging and manipulating cells and biomolecules. 2006-2007. 500K HUF. Principal investigator.
29. OTKA International Complementary Application IN 70320. Nanobiophysical study of transthyretin amyloid fibrils. 2006-2007. 2,668K HUF. Principal investigator.
30. OTKA K62317 “Von Willebrand Factor Multimer and Conformation Dependent Activity and Vascular Hematology”2006-2010. 17,041K HUF. research associate (Principal investigator Dr. Jolán Hársfalvi).
31. Italian-Hungarian TéT IT-46/2007. Nanomuscle. 2008-2010. 2,340 eFt. Principal investigator.
32. Romanian-Hungarian TéT RO-13/2007. Receptor mechanics. 2008-2009. 2,360K HUF. Principal investigator.
33. Polányi NANOAMI KFKT-1-2006-0021. Nanobiology of Amiloid ß-fibrils. 2007-2011. 155,000K HUF. Principal investigator.
34. OTKA K 73256. Structure, dynamics, mechanics, and interactions of cytoskeletal proteins: from single molecules to supramolecular systems. 2008-2011. 23,397K HUF. Principal investigator.
35. ETT 229/2009.Structure and nanomechanics of ex vivo amyloid fibrils. 2009-2011. 3,000K HUF. Principal investigator.
36. TÁMOP 4.2.1.B-09/1/KMR-2010-0001. Diagnostic Module / Head of the Development of Complex Multi-Modal Imaging Procedures; Head of the technology module. ~000K HUF.
37. OTKA 77730. Comparison of ordered and disordered protein structures by spectroscopic methods. 2009-2013. 900K HUF. research assocuiate (Principal investigator László Smeller).
38. OTKA K84133. Self-assembling amyloid network for nanoelectronic applications, 2011-2014, 32,890K HUF, Principal investigator.
39. KTIA-AIK_2012 Neuron-based infocommunication technology (nEuro-ICT): development of the first neuron-based microprocessor. Consortium leader Dr. András Málnási-Csizmadia (ELTE). Semmelweis University project head. 70,000K HUF.
40. Medinprot Synergy 2014. Exploration of molecular mechanisms of cell adhesion by TIRF microscopy. 1,300K HUF.
41. INMiND Imaging of Neuroinflammation in Neurodegenerative Diseases FP7 Proposal 278850. 2012-2017. Collaborative Project – Large-scale integrating project, 27 ueropean research groups and the KKV consortium. Semmelweis University project head. 180,000 EUR.
42. SE-MTA Molecular Biophysics Research Group. Team leader. 2012-2017. 35,000K HUF.
43. OTKA K109480 Hierarchical mechanobiology of the striated-muscle cytoskeleton, 2013-2017, 27,996K HUF. Principal investigator
44. VKSZ_14-1-2015-0052. Optopharmacology: new direction in drug research, Semmelweis University Principal investigator. 2015.08.01-2018.07.31. 149M HUF
45. VKSZ_14-1-2015-0151. Development of the new nanoScan® Plus product line – Combining PET for simultaneous data acquisition with high field strength (7T) MRI. Semmelweis University Principal investigator. 2015.09.01-2019.08.31. 50M HUF.

Current projects as Subject Leader:

1. NKFIH K135360. In situ structure and mechanics of the giant muscle protein titin. Head of topic 2020-2024. HUF 47.8 million.
2. ELKH-SE Biophysical Virology Research Group (group leader). 2022-2027. HUF 230 million.
3. NKFIH K143321. Biophysics of bacteriophage life cycle. Topic leader. 2022-2026. HUF 47,988 million.

Total amount of grant support earned as principal investigator: ~1,6B HUF (~4M USD)

Publication activity:

Scientific metrics data:
List of the scientific publications of Dr. Miklós Kellermayer in the MTMT database…

Committee memberships:

1. MTA Academic Committee of Pécs (PAB), Physics and Astrology Chapter, member (2002-2008)
2. MTA PAB Cell Biology Chapter, chair (2005-2008)
3. University of Pécs,  School of Medicine Research and Development Committee, member (2003-2005)
4. Healthcare Scientific Committee ETT-NIH Cooperative Consortium Operative Committee, member (2004-2008)
5. University of Pécs School of Medicine, Committee of Informatics of the Faculty, chair (2006-2008)
6. University of Pécs School of Medicine, Library Committee, chair (2006-2008)
7. Thesis defence committee member, University of Pécs School of Medicine, Dr. Katalin Sipos, 2002
8. Thesis defence committee member, University of Pécs School of Medicine, Dr. Attila Schwarcz, 2004
9. Thesis defence committee member, University of Pécs School of Medicine, Dr. Tamás Czömpöly, 2006
10. OTKA Infraindividual Biology 1st jury, member (2005-2008)
11. Hungarian Biophysical Society Magyar, Molecular Biophysics Chapter, secretary (since 2007)
12. University of Pécs, University Scientific Committee, member, 2007-2008
13. University of Pécs, University Committee of Informatics, member, 2007-2008
14. Thesis defence committee member, University of Pécs School of Medicine, Dr. Krisztián Kvell, 2007
15. Habilitation defence committee member, University of Pécs School of Natural Sciences, Dr. Sándor Kunsági-Máté, 2008
16. Comprehensive examination committee member, Pannon University, Anett Sebestyén, 2008
17. Comprehensive examination committee member, DE OEC Elza Friedlander, 2008
18. European Commission, NMP Expert Advisory Group, member, 2008-2012
19. Kerpel-Fronius Talent Support Program, Semmelweis University, since 2008
20. Semmelweis University’s Doctoral School, Theoretical Medical Sciences, Cellular and molecular biophysics doctoral program, Program director, since 2008
21. PhD defence committee chair, Semmelweis University, Annamária Balázs, 2009
22. MTA doctoral dissertation defence committee member, László Nyitray, 2010
23. Pázmány Péter Catholic University BSc program thesis defence committee chair, since 2012
24. Csanády László Habilitation Colloquium chair, 2013
25. OTKA BIOIN member of the jury, since 2014, chair 2016-2017

Elected board member, officer:

1. Hungarian Academy of Sciences, Biophysics Division, Secretary, 2008-2014
   1. Hungarian Academy of Sciences, Biophysics Division, Secretary, chairman, since 2014
2. Semmelweis University Senate, member, 2013-2016
3. Semmelweis University Senate, member, since 2019
4. Eötvös Loránd Research Network, steering committee, member, since 2019
5. Hungarian Biophysical Society, president, since 2023

Editorial board membership in international journals:

1. Journal of Biochemical and Biophysical Methods (2004-2007)
2. Central European Journal of Biology (since 2006)
3. Open Biomedical Engineering Journal (since 2007)
4. Journal of Biophysics (since 2007)
5. PLoS One (2011-2017)
6. EPJ Techniques and Instrumentation (since 2013)
7. Journal of Biotechnology (since 2018)

Sicence school-forming activity:

Doctoral Program, Director of the school:

• Doctoral Program in Cellular and Molecular Biophysics. Semmelweis University Doctoral School of Theoretical Medicine, since 2008.
• Director of the Doctoral School of Theoretical and Translational Medicine, since 2019

Research group leadership:

• Nanobiotechnology division. University of Pécs School of Medicine, Institute of Biophysics, South-Transdanubia Research and Development Cooperation Center. 2001-2008
• Nanobiotechnology and In Vivo Imaging researchgroup. Semmelweis University. since 2008. Current posts: 3 senior scientists, 4 postdoctoral researchers, 8 Ph.D. students, 2 assistants, 18 undergraduate research students
• High-technology instrumentation base available: in vitro motility assay, force-measuring optical tweezers, molecular force probe AFM, scanning AFM, TIRF microscope, spFRET microscope, molecular biology laboratory, confocal microscopy, muli-photon microscopy, nano-SPECT/CT scanner. nano-PET/MRI scanner, STED microscope, since 2018.

PhD thesis instruction:

Defended theses:

1. László Grama: Investigation of the global structure and elasticity of the titin giant muscle protein. 2004. 03. 02.
2. Attila Nagy: Actin-binding and mechanical properties of the titin PEVK domain. 2 05. 30.
3. Pasquale Bianco: Mechanics of titin-actin interaction explored with force-measuring optical tweezers. External Principal investigator. Florence, 2007. 03. 23.
4. Árpád Karsai: Morphology and mechanics of amyloid fibrils. 17 November 2008
5. Ünige Murvai: Amiloid fibrillumok nanomechanikai vizsgálata. 2012
6. Balázs Kiss: Nanomechanics of desmin intermediate filaments. 2012
7. András Polyák: Use of nanoparticles in nuclear medicine. 2013
8. Zsolt Mártonfalvi: Nanomechanics of the giant protein titin. 2014
9. Tamás Huber: Investigation of the mechanisms responsible for the organization of sarcomomeric filament systems. 2015
10. Zsuzsanna Vörös: Atomic force microscopy and nanomechanics of bacteriophage T7, 2018
11. Tamás Bozó: Biophysical characterization of cochlea nanoparticles. 2018
12. Tímea Feller: Morphology and nanomechanics of fibrin network by atomic force microscopy. 2019
13. Bálint Kiss: Mechanics of T7 bacteriophage DNA ejection

Current Ph.D. students:

1. Katalin Herczeg: Liposomes as pharmacological nanovehicles
2. Áron Altorjay: Self-organizing and nanomechanical properties of the actomyosin system
3. Bálint Kiss: Mechanics of T7 bacteriophage DNA ejection
4. Balázs Kretzer: Nanomechanics of nucleoprotein systems
5. Dominik Sziklai: Structure and mechanics of viruses.