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Biochem 1 (MED)

Subject matter of Medical Biochemistry 1

Spring semester of 2016/2017 academical year

  • Name of the course: Medical Biochemistry 1 Credits: 3 Neptun code: ÁOKOBI463_1A
  • Lectures:Seminars:1.5
  • Director of the course: Prof. Tretter, László MD, PhD, DSc
  • Course-coordinator: Léránt, István PhD
  • Student affairs office: EOK-Building, Room 1.508 Student affairs secretary: Mr. Zsolt Ozsváth   +36-1-4591500#60061; +36-20-6632267

The aim of the curriculum is to learn and understand the structure-funcion aspects of biologically important macromolecules (proteins, nucleic acids, lipids and complex carbohydrates) and that of their their building blocks (amino acids, nucleotides, sugars and lipids). The enzymology modul deals with the mechanism and efficiency of the in vivo biochemical reactions focusing on their organization into metabolic pathways, their regulation and effectivity. The bioenergetics modul focuses on the energy and metabolite fluxes of the human body and also settle the basis of the thermodinamycal approach of intermedier metabolism.

Lectures

Lectures

Location, time:

  • Szent-Györgyi Albert Lecture Hall, EOK-Builing, Semmelweis University Budapest IX., Tűzoltó utca 37-47 H-1094
  • Wednesday 11:00-12:40

Lecturers:

  • László Csanády MD, PhD, DSc (LCs)
  • Kraszimir Kolev MD, PhD, DSc (KK)
  • Beáta Törőcsik MD, PhD (BT)
  • László Tretter MD, PhD, DSc (LT)
W dd_mm Topic  
1 Feb:01 The role of proteins in the living world. The chemical structure of proteinogenic amino acids. (LCs)  
2 Feb:08 The peptide bond. The primary, secondary and tertiary structure of proteins. (LCs)  
3 Feb:15 The quaternary structure of proteins. The biochemical basis of protein-nucleic acid interactions. Covalent modifications of proteins. (LCs)  
4 Feb:22 Preprotein forms of proteins e.g. procollagen-collagen.  Comparison of the structure-function aspects of myoglobin and haemoglobin. (LCs)  
5 Mar:01 Thermodynamic and structural aspects of enzyme function (KK)  
6 Mar:08 Fundamentals of enzyme kinetics. (KK)  
8 Mar:20! 18:40-20:20 Regulation of enzyme activity (KK)  
  Mar:22 Enzymes as components of physiological systems (KK)  
9 Mar:29 The most important carbohydrates of the body and their presence in foodstuffs. (BT)  
10 Apr:05 The most important lipids of the body and their distribution in various foodstuffs. (BT)  
    Easter, Springbreak 10-17 April
 
11 Apr:19 The thermodynamics of biochemical pathways Reversible and irreversible reactions. The coupling of endergonic and exergonic reactions in the human body. High energy compounds. The central role of ATP in the energetics of cells. Reducing equivalents. (LT)  
12 Apr:24! 18:40-20:20 The synthesis of ATP. ATP production by substrate level phosphorylation. Oxidative phosphorylation, the production of ATP in mitochondria. The redox reactions of terminal oxidation (electron transport chain, ETC). The enzyme complexes of ETC. (LT)
 
13 May:03 Exergonic reactions in the ETC and the production of ATP. The mechanism of action of ATP synthase. The regulation of ATP production by the the energy demand of cells. The P/O ratio. The inhibitors of oxidative phosphorylation. Uncoupling agents. Heat production in special tissues of the body. (LT)  
14 May:10 The reactions of the citric acid cycle and the regulation of the pathway. (LT)  
       

Seminars

Seminars

W mm:dd Schedule of seminars
1 01:30_02:30 Nucleotides and their carbohydrate components.
2 02:06_02:10 Acid-base characteristics of amino acids, their titration curves. The isoelectric point of amino acids and their calculation.
3 02:13_02:17 Important methods in protein chemistry. 
4 02:20-02:24 Methods of protein purification and the determination of concentrations of proteins. 
5 02:27-03:03 Biochemical calculations.
6 3;06-3;10 Pathological conditions based on mutated protein structures. Amyloid proteins, prions, changes in the glycation of proteins. 
7 3;13-3;17 Determination and biological importance of kinetic parameters in theory and in clinical practice. 
8 3;20-3;24 Enzymology I. Computer simulation 1. 
9 3;27-3;31 Enzymology 2. Computer simulation 2. 
10 4;03-4;07 Role of the structures of carbohydrates and lipids in the human body. 
  4;10-4;17 Easter, springbreak
11 4;18-4;21 The macro components of nutrients: carbohydrates, lipids and proteins. 
12 4;24-4;28 The micro components of nutrients. 
13 5;02-5;05 Bioenergetics I. The connections of mitochondrial energy production and different biochemical pathways of cells 
14 5;08-5;12 Bioenergetics II. The sources of acetyl-CoA in the citric acid cycle. 

Seminar teachers

Seminar teachers

Group Day Time Seminar teacher Lecture hall
EM01&EM02 Thursday 08:00-09:10 Bak, Judit dr BA
EM03&EM04 Tuesday 14:40-16:00 Csanády, László dr (Szöllősi A) BA
EM05&EM06 Tuesday 12:10-13:20  Bak, Judit dr (Csanády L) BA
EM07&EM08 Tuesday 10:50-12:00 Szöllősi, András dr (Bak J) BA
EM09&EM10 Friday 10:00-11:10 Tóth, Erzsébet dr (Szöllősi A) BA
EM11&EM12 Tuesday 16:10-17:20 Csanády, László dr (Bak J) BA
EM13&EM14 Monday 12:00-13:10 Léránt, István dr (Szöllősi A) HP
EM15&EM16 Thursday 09:40-10:50  Szöllősi,András dr (Tóth E) HP
  • BA: Beznák Aladár Lecture Hall – Semmelweis University EOK Budapest IX., Tűzoltó utca 37-47 H-1094
  • HP: Hári Pál Lecture Hall – Semmelweis University EOK Budapest IX., Tűzoltó utca 37-47 H-1094

Text books

Text books

  • Harper’s Illustrated Biochemistry (30th edition)
  • Students’ own notes
  • Powerpoint files of lectures <<<>>> For students, Biochemistry II, authorized pages (username and password can be obtained from lab teachers)

Seminar reports

Seminar reports

During seminar time through weeks 3-12, – 10 times in total – students will have to report on the lecture and practical topics of the previous week. Missed reports cannot be made up for, students having failed to meet the requirements by week 12 may sit for a written or oral exam during weeks 13-14.

Acknowledgement of the semester

Acknowledgement of the semester

  • Three or less absences in spring semester
  • The total score of the weekly reports has to reach at least 55% of the maximum total score, and no more than two of the evaluated reports (see conditions for evaluation below) may have a score lower than 40%. Acknowledgement (and evaluation) of the semester can be obtained by successful completion of the weekly reports. Alternatively, an opportunity for a written exam on the material of weeks 1-12 will be given during week 13. In case of failure at the written exam students will be given a final opportunity to obtain a “pass” score at an oral exam during week 14.

Grading

Weekly reports during seminars will be held continuously, either in written or in oral form, as announced by the instructor. Evaluation of semester performance will be based on these reports. Failed or missed reports cannot be made up for. For those who participate at all seminars the three weakest reports will be excluded from the evaluation. For those who miss one seminar the two weakest reports, whereas for those who miss two seminars the weakest report, will be excluded. A three-scaled evaluation of semester performance will be based on these reports:

≥ – 75 % excellent (750 points from the possible 1000)

74-55 % satisfactory

54-0 % unsatisfactory

Failed students have to repeat the semester.

Students having failed to meet the semester requirements based on the weekly reports by week 12 will be given the opportunity to pass a written exam on the material of weeks 1-12 during week 13, or, in case of failure of the written exam, an oral exam during week 14. Failure to appear at the written or oral exam must be justified within three business days by submission of appropriate documents.

Topic list

Topic list

Requirements

DOWNLOADS

DOWNLOADS

Lecture slides