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MEDICAL BIOCHEMISTRY 1

Lectures

Schedule of lectures

Location, time:

  • Szent-Györgyi Albert Lecture Hall, EOK-Builing, Semmelweis University Budapest IX., Tűzoltó utca 37-47 H-1094
  • Wednesday 08:00-09:40

Lecturers: László Csanády MD, PhD, DSc (LCs); Kraszimir Kolev MD, PhD, DSc (KK); László Tretter MD, PhD, DSc (LT); Judit Bak PhD (JB); István Léránt PhD (IL)

Week dd_mm Topic
01 2019.02.06 The role of proteins in the living world. The chemical structure of proteinogenic amino acids. (LCs)
02 2019.02.13 The peptide bond. The primary, secondary and tertiary structure of proteins. (LCs)
03 2019.02.20 The quaternary structure of proteins. The biochemical basis of protein-nucleic acid interactions. Covalent modifications of proteins. (LCs)
04 2019.02.27 Preprotein forms of proteins e.g. procollagen-collagen.  Comparison of the structure-function aspects of myoglobin and haemoglobin. (LCs)
05 2019.03.06 Thermodynamic and structural aspects of enzyme function (KK)
06 2019.03.13 Fundamentals of enzyme kinetics. (KK) 
07 2019.03.20 Regulation of enzyme activity (KK) 
08 2019.03.27 Enzymes as components of physiological Systems (KK)
09 2019.04.03 The thermodynamics of biochemical pathways Reversible and irreversible reactions. The coupling of endergonic and exergonic reactions in the human body. High energy compounds. The central role of ATP in the energetics of cells. Reducing equivalents. (LT)
10 2019.04.10 The synthesis of ATP. ATP production by substrate level phosphorylation. Oxidative phosphorylation, the production of ATP in mitochondria. The redox reactions of terminal oxidation (electron transport chain, ETC). The enzyme complexes of ETC. (LT)
    Spring-break
 11 2019.04.24 Exergonic reactions in the ETC and the production of ATP. The mechanism of action of ATP synthase. The regulation of ATP production by the the energy demand of cells. The P/O ratio. The inhibitors of oxidative phosphorylation. Uncoupling agents. Heat production in special tissues of the body. (LT)
12 2019.05.01 The reactions of the citric acid cycle and the regulation of the pathway. (LT) Date, time, location is published later
13 2019.05.08 The most important carbohydrates of the body and their presence in foodstuffs. (JB)
14 2019.05.15 The most important lipids of the body and their distribution in various foodstuffs. (IL)

Seminars

Seminars

Week   Schedule of seminars
01 2019.02.04- Nucleotides and their carbohydrate components.
02 2019.02.11- Acid-base characteristics of amino acids, their titration curves. The isoelectric point of amino acids and their calculation.
03 2019.02.18- Important methods in protein chemistry. 
04 2019.02.25- Methods of protein purification and the determination of concentrations of proteins. 
05 2019.03.04- Pathological conditions based on mutated protein structures. Amyloid proteins, prions, changes in the glycation of proteins.
06 2019.03.11- Proteins – summary and consultation
07 2019.03.18- Determination of kinetic parameters of enzymes
08 2019.03.25-  Enzyme kinetics:  Biological role of kinetical parameters of enzymes 
09 2019.04.01-   Enzyme kinetics: Theory and clinical practice
10 2019.04.08-  Bioenergetics I. The connections of mitochondrial energy production and different biochemical pathways of cells.
    2019.04.15-04.22 SPRING BREAK – EASTER
 11 2019.04.23- Bioenergetics II. The sources of acetyl-CoA in the citric acid cycle.  
12 2019.04.29-  Enzymes – bioenergetics: summary and consultation.
13 2019.05.06-   Carbohydrate and lipid components of nutrients.
14 2019.05.13-  Role of the structures of carbohydrates and lipids in the human body. 

Groups - Seminar teachers

Seminar teachers (ST)

  • BA: Beznák Aladár Lecture Hall – Semmelweis University EOK Budapest IX., Tűzoltó utca 37-47 H-1094
  • HP: Hári Pál Lecture Hall – Semmelweis University EOK Budapest IX., Tűzoltó utca 37-47 H-1094
Group Day Time   ST
EM01-02 Thursday 09:40-10:50 BA Jordanov, J
EM03-04 Tuesday 08:00-09:10 BA Bartók, Á
EM05-06 Friday 13:20-14:30 HP Ambrus, A
EM07-08 Monday 10:30-11:40 HP Csanády, L
EM09-10 Wednesday 14:15-15:25 BA Léránt, I
EM11-12 Thursday 11:10-12:20 HP Szöllősi, A
EM13-14 Tuesday 11:00-12:10 BA Csanády, L
EM15-16 Friday 11:50-13:00 BA Jordanov  J

 

Text books

Text books

  • Harper’s Illustrated Biochemistry (30th edition)
  • Students’ own notes
  • Powerpoint files of lectures

Seminar reports

Seminar reports

During seminar time through weeks 3-12, – 10 times in total – students will have to report on the lecture and practical topics of the previous twoo week. The 6 test questions containing written test may result in 0-6 points. Evaluation of semester performance will be based on these reports. Failed or missed reports cannot be made up for.

A three-scaled evaluation of semester performance will be based on these reports:

0-49 % Unsatisfactory
50-74 % Satisfactory
75 -> % Excellent

Students having failed to meet the requirements by week 12 may sit for a written or oral exam during weeks 13-14 (Date, time, location are published later).

Acknowledgement of the semester

  • Three or less absences in spring semester.
  • The total score of the weekly reports has to reach at least 50 % of the maximum total score.
  • Acknowledgement (and evaluation) of the semester can be obtained by successful completion of the weekly reports. Alternatively, an opportunity for a written exam on the material of weeks 1-12 will be given during week 13. In case of failure at the written exam students will be given a final opportunity to obtain a “pass” score at an oral exam during week 14. Grading Weekly reports during seminars will be held continuously.

Failure to appear at the written or oral exam must be justified within three business days by submission of appropriate documents.

Topic list

Topic list

Requirements

DOWNLOADS

DOWNLOADS

Lecture slides

Course-outline of Medical Biochemistry 1

Spring semester of 2018/2019 academical year

  • Name of the course: Medical Biochemistry 1
  • Credits: 3
  • Neptun code: ÁOKOBI463_1A
  • Lectures:Seminars:1.5
  • Director of the course: Prof. Tretter, László MD, PhD, DSc
  • Course-coordinator: Léránt, István PhD +36-20-6632267
  • Student affairs office: EOK-Building, Room 1.508
  • Student affairs secretary: Mrs. Pichler Vera   +36-1-4591500#60061; 

The aim of the curriculum is to learn and understand the structure-funcion aspects of biologically important macromolecules (proteins, nucleic acids, lipids and complex carbohydrates) and that of their their building blocks (amino acids, nucleotides, sugars and lipids). The enzymology modul deals with the mechanism and efficiency of the in vivo biochemical reactions focusing on their organization into metabolic pathways, their regulation and effectivity. The bioenergetics modul focuses on the energy and metabolite fluxes of the human body and also settle the basis of the thermodinamycal approach of intermedier metabolism.