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MED BIOCHEM 3 2016/2017

Subject matter: Medical Biochemistry, Molecular- and Cellbiology III

Spring semester of 2016/2017 academic year

Head of Deparment of Medical Biochemistry: Prof. Tretter, László

Subject title: Faculty
Code: Credit:
Medical biochemistry, molecular and cell biology III. Medicine AOKOBI290_3A 6
Biochemistry, molecular and cell biology III Dentistry FOKOOBI159_3A 5

Integration of metabolic pathways at the level of the whole body (specific metabolic properties of separate organs, metabolic communication between organs). (i) Neurobiochemistry (membrane transporters, neurotransmitters, ion channels). (ii) Molecular basis of haemostasis, cell-cell, cell-matrix interactions, biochemistry of atherosclerosis. (iii) Biotransformation (iv) Signal transduction (hormons, biochemistry endocrine and reproductive systems).

  • Teaching secretary: Dr. István Léránt +36-1-459 1500#60034; +36-20-663 2267
  • Students Affairs Secretary: Mr. Zsolt Ozsváth EOK Building, 1st Floor, Passage ‘C’; +36-1-459 1500#60061
Holidays
Research Students’ conference February 08 – 09 -10, 2017; no lectures or seminars for second year students on 8th and 9th of February
National Holiday March 10, 2017 08:00-24:00 (Friday)
National Holiday  March 15, 2017 (Wednesday)
Springbreak, Easter April 10-14, 2017, April 17 (Easter Monday)
Faculty day April 26, 2017

Lectures

Day Time Location
Tuesday 1430-1540 Szent-Györgyi lecture hall
Thursday 0950-1100 Szent-Györgyi lecture hall

EOK-Building, Semmelweis University Budapest IX., Tűzoltó utca 37-47 H-1094

Lecturers:  Veronika Ádám  MD, PhD, DSc (VÁ), László Tretter MD, PhD, DSc (LT), László Csanády MD, PhD, DSc (LCs), Kraszimir Kolev MD, PhD, DSc (KK), József Mand MD, PhD, DSc (JM), Beáta Törőcsik MD, PhD (BT)

W M_d  
01 Jan:31 Na+,K+ ATP-ase. The permeability of cell membranes, P-type ATP-ase. Structure of Na+,K+ ATP-ase, Na+,K+ ATP-ase isoforms. Regulation. Secondary active transports. Na-H exchange 
  Feb 02 Chemical neurotransmission. Cholinergic neurotransmission. Biosynthesis of acetylcholine. receptors, acetylcholine esterase. Molecular mechanism of exocytosis (VÁ)
02 Feb 07  Noradrenergic neurotransmission. Biocynthesis and metabolism of norepinechpirne. Synaptic upatek (VÁ)
  Feb 09 Reseach Student’s Conference
03 Feb 14 Molecular mechanisms of adrenergic, dopaminergic and serotoninergic neurotransmission (VÁ)
  Feb 16  GABAergic neurotransmission (VÁ)
04 Feb 21 NO: Regulatory role of NO. Nitric oxide synthase. Guanylate cyclase. Molecular effects of nitric oxde (VÁ)
  Feb 23 Glutamatergic neurotransmission (VÁ)
05 Feb 28 General properties of ion channels. Methods for studying ion channels (LCs)
  Mar 02 Structure of the K+ channels. Methods for studying ion channels. The molecular mechanism of gating and permeation ((LCs)
06 Mar 07 Haemostasis I: General overview of blood clot formation and elimination. Fibrinogen and fibrin. Prothrombin activation and regulation of thrombin activity. Triggers of blood clotting, amplification of the initiation signals and negative  feedbanck mechanisms. Inhibitors of blood coagulation (KK)
  Mar 09 Haemostasis II: Fibrinolysis. Plasminogen activation. Fibrinolytic inhibitors. Biochemical backgrounds of haemophylia, thrombophylia and anticoagulant therapy (KK)
07 Mar 14 Haemostasis III: Cellular elements of haemostatic system. Platelets and von Willebrand factor (KK)
  Mar 16 Haemostasis IV: Neutrophils and endothlial cells n haemostasis. Adhesion molecules (cadherins, selectins, IgSF cellular molecules, integrins (KK)
08 Mar 21 Haemostasis V: Pathobiochemistry of  atherothrombosis and atherosclerosis. Endothelial dysfunction. LDL oxidaton and pattern-recognition receptors (Toll-like receptors, scavenger receptors). Risks factors of atheroschlerosis related to cholesterol homeostasis (diabetes, hypertriglyceridemia). Biochemical background of atheroschlerosis, prevention) (KK).
  Mar 23 Biotransformation 1 (JM)
09 Mar 28 Biotransformation 2 (JM)
  Mar 30 Signaltransduction 1 (JM)
10 Apr 04 Signaltransduction 2 (JM)
  Apr 06 Signaltransduction 3 (JM)
    Springbreak (10-17)
11 Apr 18 Signaltransduction 4: Therapeutic targeting of signal transduction pathways  (BT)
  Apr 20 Signaltransduction 5: Calcium signalling (BT)
12 Apr 25 The role of thyroid hormones (LT)
  Apr 27 Apoptosis 1: Different types of cell death. The physiological role of apoptosis. Pathways of apoptosis (BT)
13 May 02 Apoptosis 2:Effector mechanisms and inhibition of apoptosis. The morphology of programmed cell death. Aberrant survival pathways in cancer cells. (BT)
  May 04 Oncogens (LT)
14 May 09 Tumor supressor oncogens (LT)
  May 11 Mechanisms of human oncogenes (LT)
     

 

Lab. lessons

Week Date  Laboratory lesson / seminar  
1.  Jan 30-Feb 03 THE ISOENZYME PROFILE OF LACTATE DEHYDROGENASEDiscussion: AMI (acute myocardial infraction ) and laboratory diagnosiss  
2. Feb 06-10 Acute and chronic liver disease (seminar)  
3. Feb 13-17 Determination of TRANSAMINASE ENZYME ACTIVITIES and DETERMINATION OF CREATINE-KINASE ACTIVITY IN SERUM – Discussion: Liver disease and laboratory diagnosis  
4. Feb 20-24 Bioinformatics (computer skills) (DATE, TIME, LOCATION)  
5. Feb 27-Mar 03 Metabolism of exercise (seminar)  
6. Mar 06-10 Laboratory lesson:  DETERMINATION OF BLOOD GLUCOSE LEVEL and  DETERMINATION OF GLYCOSYLATED HAEMOGLOBIN Discussion: Non-enzymatic covalent modification of proteins; AGE (avadvanced glycation end products) – role in pathology of diabetic complications  
7. Mar 13-17 Metabolism of tumors (seminar)  
8. Mar 20-24 EXPERIMENTAL MODELS OF BLOOD COAGULATION  – Discussion: Diagnostic evaluation of disorders of Haemostasis  
9. Mar 27-31 Haemostatic abnormalities (seminar);  
10. Apr 04-07

THE K+, Na+ TRANSPORT ATP-ase 

 
    Spring holiday + Eastern Monday  
11. Apr 18-21  Cell adhesion (seminar)    
12. Apr 24-28

Extracellular matrix (seminar) (tumor metastasis, wound healing, angiogenesis, liver fibrosis)

For groups EM11 and EM10 Investigation of microsomal drog metabolism

 
13. May 02-05 Investigation of microsomal drog metabolism  – Discussion: Molecular basis of drug interactions  
14. May 08-12 Research of specific literature of Biochemistry. Presentation of research at our department (Consultation)  

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

Computer skills “Enzyme kinetics” (Week  6) are held at laboratories of informatics of Semmelweis University. 

Groups

Group Room# Day Time Laboratory/seminar teacher
ED1   Wednesday 08:00-10:30 Vér,  Ágota dr
ED2   Wednesday 08:00-10:30 Léránt, István dr
ED3   Wednesday 08:00-10:30 Farkas, Veronika dr
ED4   Wednesday 08:00-10:30 Bak, Judit  dr/ Horváth, Gergő dr
         
EM01   Tuesday 09:45-12:15 Chinopoulos, Christos dr
EM02   Wednesday 08:00-10:30 Müllner, Nándor dr
EM03   Thursday 13:15-15:45 Tóth, Erzsébet dr
EM04   Thursday 13:15-15:45 Törőcsik, Beáta dr
EM05   Tuesday 09:45-12:15 Bartha, Katalin dr
EM06   Friday 08:00-10:30 Csala, Miklós dr
EM07   Tuesday 09:45-12:15 Hrabák, András dr
EM08   Thursday 13:15-15:45 Kolev, Kraszimir dr
EM09   Tuesday 09:45-12:15 Komorowicz, Erzsébet dr
EM10   Monday 13:45-16:15 Bak, Judit dr, Horváth, G dr
EM11   Monday 08:00-10:30 Kolev, Kraszimir prof
EM12   Thursday 13:15-15:45 Mészáros, Tamás dr
EM13   Wednesday 10:45-13:15 Komáry, Zsófia dr
EM14   Tuesday 09:45-12:15 Léránt, I dr / Törőcsik, B dr
EM15   Wednesday 10:45-13:15 Keszler, Gergely dr

Recommended books

2nd (oral) retake examination

The second oral retake of the 1st and 2nd midterm exams is held on Monday. (May 8,  2017; 17:00 (week 14); at the biochemistry  laboratory rooms  of Department of Medical Biochemistry; Budapest IX., Tűzoltó utca 37-47, 1st floor, passage ’C’), for those  students who haven’t passed either the 1st  or the 2nd  midterm exams. Those regular students may also come for the retake, who failed both midterm exam tests.

The examining committees will consist of 2 members and have the following composition:  (i) the Supervisor; (ii) and a Chair.

We ask you to come to our Student Affair Office (room 1.508) for 17:00 and contact there Mr Zsolt Ozsváth. The examining committee shall be chosen by lot.

The oral midterm exam (1st midterm examination) consists of 2 questions (neurobiochemistry and seminars: acute and chronic liver disease, metabolism of exercise).

The oral midterm exam (2nd midterm examination) consists of 2 questions (haemostasis + biotransformation).

At the end of the examination, members of the examination committee, including the Chair, will vote.  If any modules (neurobiochemistry and seminars; haemostasis + biotransformation) show a status of ’1 (fail)’, – this means you have failed your oral retake of midterm examination.

Topic list for the 1st midterm examination

  1. General properties of ion channels. Methods for studying ion channels.
  2. Structure of the K+ Methods for studying ion channels. The molecular mechanism of gating and permeation.
  3. Na+ , K+  ATP-ase. The permeability of cell membranes, P-type ATP-ase. Structure of Na+, K+ -ATP- ase; Na+, K+ -ATP- ase isoforms. Regulation. Secondary active transports. Na-H exchange.
  4. Chemical neurotransmission. Cholinergic neurotransmission. Biosynthesis of acetylcholine, receptors, acetylcholine esterase. Molecular mechanism of exocytosis.
  5. Noradrenergic neurotransmission. Biosynthesis and metabolism of norepinephrine. Synaptic uptake.
  6. Molecular mechanisms of adrenergic, dopaminergic and serotoninergic neurotransmission.
  7. Acute and chronic liver disease
  8. Metabolism of exercise

Topic list for the 2nd midterm examination

  1. Hemostasis I: General overview of blood clot formation and elimination. Fibrinogen and fibrin. Prothrombin activation and regulation of thrombin activity. Triggers of blood clotting, amplification of the initiation signals and negative feedback mechanisms. Inhibitors of blood coagulation.
  2. Hemostasis II: Fibrinolysis. Plasminogen activation. Fibrinolytic inhibitors. Biochemical background of haemophilia, thrombophilia and anticoagulant therapy.
  3. Hemostasis III: Cellular elements of the haemostatic system. Platelets and von Willebrand factor.
  4. Hemostasis IV: Neutrophils and endothelial cells in Hemostasis. Adhesion molecules (cadherins, selectins, IgSF cellular molecules, integrins).
  5. Hemostasis V: Pathobiochemistry of atherothrombosis and atherosclerosis. Endothelial dysfunction. LDL oxidation and pattern-recognition receptors (Toll-like receptors, scavenger receptors). Risk factors of atherosclerosis related to cholesterol homeostasis (diabetes, hypertriglyceridemia). Biochemical background of atherosclerosis prevention

Midterm exam1

  • 1st midterm exam is held on the 6th of March at 17:30 o’clock at Szent-Györgyi Albert lecture hall  for groups EM1, EM3, EM4, EM5, EM8, EM9, EM11, EM12, EM13, EM14, EM15 and at the lecture hall of 2nd Department of Obsterics and Gynaecology (Budapest VIII., Üllői út 78/a) for groups EM2, EM6, EM7, EM10, ED1, ED2, ED3, ED4, FMMED, FMDEN.
  • 1st retake of the 1st midterm is held on the 13th of March at 17:30-18:50 o’clock at lecture hall of 2nd Department of Obstetrics and Gynaecology Budapest VIII., Üllői út 78/A
  • 2nd oral retake of the 1st midterm exam is held on the 8th of May at 17:00 o’clock  in the laboratory rooms of our Department

Topics

  • General properties of ion channels. Methods for studying ion channels.
  • Structure of the K+ channels. Methods for studying ion channels. The molecular mechanism of gating and permeation.
  • Na+, K+ ATP-ase. The permeability of cell membranes, P-type ATP-ase. Structure of Na, K-ATP-ase; Na, K-ATP-ase isoforms. Regulation. Secondary active transports. Na-H exchange.
  • Chemical neurotransmission. Cholinergic neurotransmission. Biosynthesis of acetylcholine, receptors, acetylcholine esterase. Molecular mechanism of exocytosis.
  • Noradrenergic neurotransmission. Biosynthesis and metabolism of norepinephrine. Synaptic uptake.
  • Molecular mechanisms of adrenergic, dopaminergic and serotoninergic neurotransmission.
  • Glutamatergic neurotransmission. Synthesis, transporters, receptors. Biochemistry of Parkinson disease.
  • Acute and chronic liver disease
  • Metabolism of exercise

25 multiple choice type questions and 2 biochemistry problem sets (panels) are asked. Students may obtain 1 score for each correctly solved multiple choice questions. The both problem sets are evaluated by your own laboratory teachers (points: 0, 2, 3, 4, 5).  We calculate the sum of your scores and points of your midterm examinations and the tests are graded by the proposed limits of the table below:

Proposed limits for the marks of midterm are:

Sum of the grades and scores Grade of the midterm examination
0-18 1 (fail)
19-22 2 (pass)
23-26 3 (satisfactory)
27-30 4 (good)
31-35 5 (excellent)

The grade for the midterm exam is 1 (fail), if (i) the sum of the scores and the points is 18, or less (ii) each of the problem sets are evaluated by 0.

  • Students who are ill at the time of the 1st midterms can compensate their absence on the 13th of March, 2017 at 17:30-18:50 o’clock at lecture hall of 2nd Department of Obstetrics and Gynaecology Budapest VIII., Üllői út 78/A (1st midterm exam – 1st retake), after presenting medical certificate.
  • Students having failed the first retake may sit for the second retake in week 14. The second retake is an oral exam conducted by an examination committee. Students having failed the first retake of both midterms I and II will be examined in the material of both midterms at the same time.

Deadline for the presentation of the medical certificate:  1st midterm examination: March 9, 2017.  The medical certificates are accepted by Mr. Zsolt Ozsváth, at our Students’ Affairs Office, Budapest IX., Tűzoltó utca 37-47, H-1094 1st floor, passage “C” room# 1.508 Phone: #60061,

  • Passing both midterms is a prerequisite to acknowledgement of the semester.
  • Failed midterms might be retaken twice
  • No opportunity for the retake of failed midterm exams is given for our FM students, but their former electronic signature is accepted for the final-examination!
  • Students having failed the first retake might sit for the second retake in the last week of the semester. The second retake is an oral exam conducted by an examination committee. Students having failed the first retake of both midterms I and II will be examined in the material of both midterms at the same time.

2nd oral retake of the failed midterm exams

The second oral retake of the 1st and 2nd midterm exams is held on Monday. week 14. ( May 8,  2017; 17:00; biochemistry  laboratory rooms  of Department of Medical Biochemistry; Budapest IX., Tűzoltó utca 37-47, 1st floor, passage ’C’), for those  students who haven’t passed either the 1st  or the 2nd  midterm exams. Those regular students may also come for the retake, who failed both midterm exam tests.

The examining committees will consist of 2 members and have the following composition:  (i) the Supervisor; (ii) and a Chair.

We ask you to come to our Student Affair Office (room 1.508) for 17:25 and contact there Mr Zsolt Ozsváth. The examining committee shall be chosen by lot.

Midterm exam 2

  • 2nd midterm exam is held on the 27th of March at 17:30 o’clock at Szent-Györgyi Albert lecture hall (EOK Building) for groups EM1, EM3, EM4, EM5, EM8, EM9, EM11, EM12, EM13, EM14, EM15 the lecture hall of 2nd Department of Obsterics and Gynaecology (Budapest VIII., Üllői út 78/a) for groups EM2, EM6, EM7, EM10, ED1, ED2, ED3, ED4, FMMED, FMDEN.
  • 1st retake of the 2nd midterm exam is held on the 3rd of April 17:30 o’clock at Szent-Györgyi Albert lecture hall.
  • 2nd oral retake of the 2nd midterm exam is held on the 8th of May 2017   in the laboratory rooms of our Department

Hemostasis I: General overview of blood clot formation and elimination. Fibrinogen and fibrin. Prothrombin activation and regulation of thrombin activity. Triggers of blood clotting, amplification of the initiation signals and negative feedback mechanisms. Inhibitors of blood coagulation.

Hemostasis II: Fibrinolysis. Plasminogen activation. Fibrinolytic inhibitors. Biochemical background of haemophilia, thrombophilia and anticoagulant therapy.

Hemostasis III: Cellular elements of the haemostatic system. Platelets and von Willebrand factor.

Hemostasis IV: Neutrophils and endothelial cells in Hemostasis. Adhesion molecules (cadherins, selectins, IgSF cellular molecules, integrins).

Hemostasis V: Pathobiochemistry of atherothrombosis and atherosclerosis. Endothelial dysfunction. LDL oxidation and pattern-recognition receptors (Toll-like receptors, scavenger receptors). Risk factors of atherosclerosis related to cholesterol homeostasis (diabetes, hypertriglyceridemia). Biochemical background of atherosclerosis prevention.

 

25 multiple choice type questions and 2 biochemistry problem sets (panels) are asked. Students may obtain 1 score for each correctly solved multiple choice questions. The both problem sets are evaluated by your own laboratory teachers (points: 0, 2, 3, 4, 5).  We calculate the sum of your scores and points of your midterm examinations and the tests are graded by the proposed limits of the table below:

Proposed limits for the marks of midterm are:

Sum of the grades and scores Grade of the midterm examination
0-18 1 (fail)
19-22 2 (pass)
23-26 3 (satisfactory)
27-30 4 (good)
31-35 5 (excellent)

The grade for the midterm exam is 1 (fail), if (i) the sum of the scores and the points is 18, or less (ii) each of the problem sets are evaluated by 0.

  • Students who are ill at the time of the 2nd midterms can compensate their absence on the 03th of April, 2017 at 17:30-18:50 o’clock at lecture hall of 2nd Department of Obstetrics and Gynaecology Budapest VIII., Üllői út 78/A (1st midterm exam – 1st retake), after presenting medical certificate.
  • Students having failed the first retake might sit for the second retake in week 13. The second retake is an oral exam conducted by an examination committee. Students having failed the first retake of both midterms I and II will be examined in the material of both midterms at the same time.

Deadline for the presentation of the medical certificate: (i) 1st midterm examination: March 9, 2016. (ii) 1st retake of 1st midterm: March 18, 2016. The medical certificates are accepted by Mr. Zsolt Ozsváth, at our Students’ Affairs Office, Budapest IX., Tűzoltó utca 37-47, H-1094 1st floor, passage “C” room# 1.508 Phone: #60061,

  • Passing both midterms is a prerequisite to acknowledgement of the semester.
  • Failed midterms might be retaken twice
  • No opportunity for the retake of failed midterm exams is given for our FM students, but their former electronic signature is accepted for the final-examination!
  • Students having failed the first retake might sit for the second retake in the last week of the semester. The second retake is an oral exam conducted by an examination committee. Students having failed the first retake of both midterms I and II will be examined in the material of both midterms at the same time.

2nd oral retake of the failed midterm exams

The second oral retake of the 1st and 2nd midterm exams is held on Monday. week 14. (May 8,  2017; 17:00; biochemistry  laboratory rooms  of Department of Medical Biochemistry; Budapest IX., Tűzoltó utca 37-47, 1st floor, passage ’C’), for those  students who haven’t passed either the 1st  or the 2nd  midterm exams. Those regular students may also come for the retake, who failed both midterm exam tests.

The examining committees will consist of 2 members and have the following composition:  (i) the Supervisor; (ii) and a Chair.

We ask you to come to our Student Affair Office (room 1.508) for 17:55 and contact there Mr Zsolt Ozsváth. The examining committee shall be chosen by lot.

Requirements

Neptun codes: AOKOBI290_3A; FOKOOBI159_3A Credit: 6; 5

Lecturer: László Tretter MD, PhD, DSc, head of Department of Medical Biochemistry Teaching secretary: István Léránt PhD, senior lecturer

Lectures: Tuesday 1430-1540 Thursday 0950-1100 (3 hours/week) Szent-Györgyi Albert Lecture Hall, EOK-Building, Semmelweis University, Budapest IX., Tűzoltó utca 37-47. H-1094

 

Schedule of laboratory lessons and seminars

Laboratory exam

A facultative laboratory exam is held for our regular students on the 14th week of the spring semester of 2016/2017 academic year. The test is held in the first 15 Min of the last week seminar, postponement of the exam is not allowed.

Date: 09-13 May, 201y, Laboratory rooms of the Department

Material: the topics of  the laboratory lessons of the

  • spring semester – 2015-2016 academic year
  • fall semester – 2016-2017 academic year
  • spring semester – 2016-2017 academic year

Evaluation: the tests are evaluated by 2 or 1 point/s or they are not accepted (NA).

If you pass our ‘L‘ test (laboratory exam), your semifinal exam consists ‘only’ the ‘T’ test  (theoretical written test). If your ‘L’ test is not accepted (na), you have to pass the both parts – ‘L’ and ‘T’ test in December or in January.

Results of the tests is published on the 15th or 16th of May (link ‘lecture slides’)

  1. Amino acids and proteins I. Reversible and irreversible precipitation of proteins, precipitation of casein at isolectric point.
  2. Amino acids and proteins II. Quantitative colorimetric determination of proteins (biuret method, Ellmann reaction).
  3. Experimental determination of enzyme kinetic parameters of urease.
  4. Inhibition of urease activity by substrate analogues and -SH reagents.
  5. Separation by gel-filtration.
  6. Separation by paper- and thin-layer chromatography.
  7. Separation and identification of proteins by gel-electrophoresis and immunoblotting.
  8. Induction of ß-galactosidase
  9. Restriction digestion of pGL3 basic vector and separation of DNA fragments electrophoresis
  10. Experimental determination of enzyme kinetic parameters (Computer skills)
  11. Competitive inhibition of succinate dehydrogenase by malonate
  12. Mitochondrial oxidation I.: Experimental conditions for determination of oxygen consumption by intact mitochondria. Definition and experimental measurement of P/O ratio.
  13. Mitochondrial oxidation II.: Please draw the curve of mitochondrial oxygen consumption after consecutive addition of glutamate/malate – ADP – atractylozide – DNP – oligomycin – CN-. Explain the curves briefly.
  14. Differential regulatory mechanisms of behaviour of L- and M-type isoenzymes of pyruvate kinase: effect of allosteric ligands on activity
  15. Digestion of lipids, determination of lipase activity
  16. Plasma lipoproteins and lipid determination of plasma cholesterol and triglyceride level
  17. Isolation of trypsin by affinity chromatography. Characterization of the substrate specificity of trypsin and chymotrypsin.
  18. The isoenzyme distribution of lactate dehydrogenase.
  19. Transaminase enzyme activities. Determination of creatine-kinase enzyme activity in serum.
  20. Bioinformatics (computer skills).
  21. Determination of blood glucose level. Determination of glycosylated hemoglobin.
  22. The K+,Na+ ATP-ase acitivity.
  23. The experimental models of blood coagulation: the prothrombin time, activated partial thromboplastin time
  24. Fibrin polymerization and stabilization, thrombin-antithrombin inactivation
  25. The investigation of microsomal drogmetabolism.

Competition

   

Results of the biochemistry competition 2017

Date: May 8, 2017, 17:30 SZENT-GYÖRGYI ALBERT Lecture Hall (Budapest IX., Tűzoltó utca 37-47, H-1094)

Registration –  Competition of Medical Biochemistry, Molecular and Cell Biology III

(Scroll down and fill  the google-sheet and click the blue “küldés” link to forward to us your name, group, neptun code, your grades of midterms)

Material: lectures, seminars and laboratory lessons of the fall and spring semesters of 2016/2017 and spring semester of the 2015/2016 academic year
Test: biochemistry problems and structures (max. 30 + 10) + 70 multiple choice type questions
Students reaching at least 75 % will be exempted from the examination by mark 5
Other exemptions are not possible
Conditition: Only registered students may come.  Regular students of groups EM01-EM15 and ED01-ED04 may register for the competition whose midterm exam 1 and 2 were graded by 3, 4 or 5. (FM students or students who registered for the medical biochemistry, molecular and cell biology III this semester the second or the third time may not register for the biochemistry competition).

Registration starts on the 25st of April, 201y. Registration is closed on the 3rd of May

Final examination

Final-examination of students registered at subject matter Medical Biochemistry, Molecular and Cell Biology III / Biochemistry, Molecular and Cell Biology III

Final-examinations of Medical Biochemistry, Molecular and Cell Biology III and Biochemistry, Molecular and Cell Biology III are held on Tuesdays and Thursdays.

The grade of the final exam is based on 4 elements:

  1. Laboratory exam (L) (na/0, 1, 2, max 2 points)
  2. Grades of midterm exam #1 and #2 converted to points (M) (max 10 points)
  3. Theoretical written test ( biochemistry problem set + multiple choice type tests) (T) (3 blocks, max 100 points)
  4. Bonus points collected in the course of the spring semester (B) max 7 points

Laboratory examination (L) The laboratory examination is an obligatory part of the final-examination. Students get one question based on the attached „list of laboratory questions” and answer it in written form (in 15 Min). These tests are graded by 0, 1, 2 points. Students cannot pass the final- examination with 0 point from the practical exam. Department of Medical Biochemistry gives the students a chance to write their laboratory tests as midterm exam#3 on the last week of the semester. These tests are graded by 1 or 2 points; unsuccessful tests are only marked as ‘not accepted’. Results of the midterm exam#3 are accepted as the results of laboratory exam of exam period.

Results of the midterm examinations (M) Grades of the 1st midterm examinations as points are added to the scores of second block, the grades of 2nd midterm examination as points are added to the third block. (Unsuccesfully completed mindterm exam/s result/s in the lack of acknowledgement of the semester).

Theoretical written test (biochemistry problem sets and multiple choice type tests (T)) (max. 100 points)

  • Block#1: biochemistry problem set (max 30 points)
  • Block#2: multiple choice type questions (max 35 points)
  • Block#3: multiple choice type questions (max 35 points)

Bonus points collected in the course of the semester (B) Maximal number of ‘bonus points’ for the spring semester is 7. These bonus points can be collected in the course of fall semester according to the following scheme: from the grading of the experimental work (see ‘Grading of the performance of the laboratory work’)

  • 3 points, if the sum of the collected experimental points is at least 7
  • 2 points, if the sum of the collected experimental points is at least 6
  • 1 point, if the sum of the collected experimental points is at least 5

from oral presentations on the seminars accompanied by power point presentations or written summaries in electronic format, which are distributed through the on-line teaching system (max. 4 points)

Grades of the final examination

Total scores from the 4 elements of the semi-final examination = L + M + T + B

T + L + M + B Grade
if the first block contain 14 scores or less and/or the second and third blocks contain 17 scores or less and / or the laboratory test is graded by 0 and / or the sum of the T+L+M+B values is 61 or less. Fail (1)
62-75 Pass (2)
76-89 Satisfactory (3)
90-103 Good (4)
104-119 Excellent (5)

Students who pass blocks 1-2-3 and the sum of M+T+B is 61 or higher, but fail on the practical essay (L) have to retake only the practical essay (L) when they repeat the final exam; students who pass the laboratory examination (L) but fail on the written test (blocks 1-2-3) have to retake the blocks 1-2-3. Those who want better grade are entitled to rewrite also the first 3 blocks, however, with the risk of performing worse.

‘1 point rule’

 

Block 1

Block 2

Block 3

Block#1 14 points Block#2 18 points or more Block#3 18 points or more
Block#1 15 points or more Block#2 17 points Block#3 18 points or more
Block#1 15 points or more Block#2 18 points or more Block#3 17 points

if block#1 contains 14 points or,
if block#2 contains 17 points or,
if block#3 contains 17 points

and the others contain 15/18/18 points or more (T) + the laboratory exam is evaluated by either 1 or 2 points (L), the grade for final-examination is 2 (pass) if the sum of scores and points (T+L+M+B) are 65 points or higher.

Lab-bonus points, presentation bonus points, midterm grades of former semesters (spring semester of 2015/2016 academic year, or earlier) are not accepted.

Topic list

Exemption

  1. Exemption may be given only if students pass an exemption examination
  2. Prerequisite of participating in the exemption exam: previous studies and successful examinations in the subject Biochemistry (final exam) (Biochemistry I, II, III)
  3. Documents to be attached on the previous studies:

a transcript from the former University, containing the name of courses taken in Biochemistry, examination grades and a copy of your final BSc or MSc diploma (if you have)

a topic list of Biochemistry (bioenergetic, metabolism of carbohydrates, lipids, amino acids, nucleotides, biochemistry of tissues, neurobiochemistry, signal transduction, haemostasis and/or molecular biology (macromolecules) (for final exam) (Only official hardcopy version of documentation is accepted, we do not accept e-documentation).

the indication of the used textbook(s) is also recommended

will be organized by our examination committee.

  1. Oral examinations in Biochemistry
  1. The exemption examinations take place on the 5th or 6th week of the semester (Febr 29-04 or March 7-11, 2016); the deadline to present your documents is the end of the 2nd week (February 12, 2016).
  2. In case of unsuccessful exemption examination there are not any negative consequences. You have to attend laboratory lessons and seminars throughout the semester and sit for the regular examination at the end of the semester like the rest of students.

dr. Gergely Keszler

dr. István Léránt

teaching secretary of 1st year program in Chemistry and Biochemistry I.

teaching secretary of 2nd year program in Biochemistry II-III

keszler.gergely@med.semmelweis-univ.hu

lerant.istvan@med.semmelweis-univ.hu

 

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