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Biochem 2 (MED) 2017/2018

Lectures

Lecturers:  Beáta Törőcsik MD, PhD (BT); István Léránt (IL); prof. Kraszimir Kolev MD, PhD, DSc (KK); József Mandl MD, PhD, DSc (JM); Erzsébet Komorowicz MD, PhD (EK)

     
Tuesday 15:35-16:45 Szent-Györgyi Albert lecture hall
Thursday 09:20-10:30 Szent-Györgyi Albert lecture hall
     
Week   Metabolism of carbohydrates
01 2018.09.11 Carbohydrates. Digestion and absorption of carbohydrates, cellular glucose uptake, glucose transporters  BT
  2018.09.13 Glycolysis BT
02 2018.09.18 Metabolism of fructose and galactose. Gluconeogenesis. Cori-cycle  BT
  2018.09.20 Regulation of glycolysis and gluconeogenesis. Oxidation of alcohol and carbohydrate metabolism BT
03 2018.09.25 Metabolism of glycogen. Mobilization of glycogen in liver and muscle BT
  2018.09.27 Blood glucose level and its regulation: hyperglycaemia. Insulin release, insulin receptors BT
04 2018.10.02 Biochemistry of diabetes mellitus (DM) type I and type II DM  BT
    Metabolism of lipids
  2018.10.04 Metabolism of lipids – overview. Absorption of lipids. Metabolism of chylomicrons IL
05 2018.10.09 Mobilization of fatty acids in adipose tissue, its regulation. Transport in circulation. Free fatty acids, VLDL, IDL IL
  2018.10.11 Oxidation of fatty acids, ketone bodies IL
06 2018.10.16 Synthesis of fatty acids IL
  2018.10.17 Biosynthesis of triacylglycerol, phospholipids, their regulation IL (Wednesday 16:30-17:40)
  2018.10.18 Metabolism of cholesterol, cholesterol transport in circulation KK
07 2018.10.24 Biosynthesis and metabolism of the bile acids, the importance of bile acids in lipid digestion. Cholesterol uptake and release by cells KK (Wednesday 16:30-17:40)
  2018.10.25 Pathobiochemistry of atherosclerosis KK
    Biotransformation
08 2018.10.30 Characterization and classification of reactions in biotransformation. Phase I and Phase II reations. Clinical significance of induction JM
09 2018.11.06 Role of biotransformation in drug metabolism and detoxification. Metabolism of ethanol and its pathobiochemical effects JM
    Amino acids
  2018.11.08 Nitrogen balance. Digestion of proteins. Function of proteases, their regulation. Absorption of amino acids, amino acid transporters IL
10 2018.11.13 Catabolism of amino acids. Elimination of ammonia, reactions of ornithine cycle. Its regulation IL
  2018.11.15 Catabolism of amino acids. Catabolism of carbonic skeleton IL
11 2018.11.20 Catabolism of amino acids. Catabolism of carbonic skeleton. Role of vitamins in amino acid metabolism IL
  2018.11.22 Biosynthesis of nonessential amino acids and other amino acid derivatives IL
    Metabolism of nucleotides; synthesis and degradation of heme
12 2018.11.27 Structure and function of nucleotides. The fate of diatary nucleotides. Formation and elimination of uric acid, its metabolic role in humans. Molecular basis of gout. KK
  2018.11.29 Synthesis and degradation of purine and pyrimidine nucleotides. Effects of cytostatic drugs on nucleotide metabolism. KK
13 2018.12.04 Biosynthesis and degradation of heme. Homeostasis of iron.  KK
    Steroid hormones, eicosanoids
  2018.12.06 Synthesis of steroidal hormones in adrenal cortex. Synthesis of glucocorticoids. Biochemical background of adrenal cortex layers. Synthesis of mineralocorticoids, its regulation, prereceptor specificity. Effect of cortisol, regulation of cortisol synthesis. Androgen production of adrenal cortex EK
14 2018.12.11 Synthesis of sex hormones. Ovarian cyclic hormone production. Biosynthesis of progesterone and estradiol in placenta. Synthesis of testosterone in testis, formation and importance of dihydrotestosterone EK
  2018.12.13 Eicosanoids: synthesis of prostaglandins, thromboxanes and leukotriens (cyclooxygenase and lipoxigense pathway) EK

Lab. lessons

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

 Week  MM.dd:dd  
01 09.11:15 Safety rulesSafety rules for work in the laboratory Priciples of bioenergetics (Seminar)
02 09.18:22 Competitive inhibition of succinate dehydrogenase (lab)
03 09.25:29 Lactic acidosis (Seminar)
04 10.01:06 Fructose intolerance & McArdle’s disease (Seminar)
05 10.09:13 Oxidative phosphorylation in mitochondria (lab)
06 10.16:20 Enzyme kinetics – computer simulation (lab)
07 10.24:30 Allosteric regulation of pyruvate kinase  ASSAY (PK) (lab)
08 11.31:03 Signaltransduction of insulin (Seminar)
09 11.06:10 Digestion of lipids, role of bile acidsSubstrate specificity of trypsin and chymotrypsin. (lab)
10 11.13:17 Lipoprotein lipase, & carnitine deficiency (Seminar)
11 11.20:24 Glutamate dehydrogenase
12 11.27:01 Hereditary hyperammonemias. (Seminar)
13 12.04:08 Determination of serum cholesterol and triglyceride (lab)
14 12.11:15 Vitamin B12 deficiency, methylmalonic acidemia (Seminar)

Groups

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

Day Time Group  
Monday 08:00-10:10 EM03 Kolev, K prof
  08:00-10:10 EM05 Bartha, K
  08:00-10:10 EM07 Komorowicz, E
Monday 10:40-13:10 EM14 Kolev, K prof
  10:40-13:10 EM15 Léránt, I
Monday 13:40-15:50 EM13 Dóczy, J
Tuesday 10:40:12:50 EM02 Müllner, N
  10:40:12:50 EM04 Törőcsik, B
  10:40:12:50 EM06 Komáry, Zs
  10:40:12:50 EM10 Chinopoulos, C
  10:40:12:50 EM12 Mészáros, T
Friday 08:00-10:10 EM01 Bak, J
Friday 10:40-12:50 EM08 Margittai, É
  10:40-12:50 EM09 Tóth, E
  10:40-12:50 EM11  

 

Recommended books

Midterm exam

  • Oral retake of failed midterms (1 and/or 2) Week 13, Dec 6, 2017 Wednesday 16:30-20:00 EOK Dept Biochem – Laboratory room 4, 5 and 3
  • Passing both midterms is a prerequisite to acknowledgement of the semester.
  • Midterm examination 2: Week 11. Nov 22, 2017  Wednesday 16:30-17:50 & 18:00-19:20 EOK Szent-Györgyi Albert Hall Midterm exam # 2 (Medical Biochemistry 2)
    • Midterm examination 2-retake: Week 12. Nov 29, 2017  Wednesday 16:30-17:50- EOK Szent-Györgyi Albert Hall 
  • Midterm examination 1: Week 7. Oct 25, 2017  Wednesday 16:30-17:50 & 18:00-19:20 EOK Szent-Györgyi Albert Hall – Midterm exam # 1 {Medical Biochemistry 2 (MED)
    • Midterm examination 1-retake: Week 9. Nov 08, 2017  Wednesday 16:30-17:50  EOK Szent-Györgyi Albert Hall 
  • Grading of midterm

Requirements

Laboratory exam

Competition

   

Results of competition

Date: Dec 13, 2017, 16:45 EOK-Building, Szent-Györgyi Albert Lecture Hall
Material: lectures, seminars and laboratory lessons of the fall semesters of 2017/2018 academic year.

Students reaching at least 75 % will be exempted from the examination by mark 5. Other exemptions are not possible.

Conditition: 

  • grades 3 or better  at both midterms (grade of midterm exams of Oct 25/Nov8, Nov 22/Nov 29)
  • registration for the subject matter of Medical Biochemistry II in the fall semester of 2017/2018 academic year
  • registration for the subject matter of Medical Biochemistry I in the spring semester of 2016/2017 academic year

Registration: starts on the 1 Dec, 2017. Registration is closed on the 8th of December, 2017

 

DOWNLOADS

Subject matter: Medical Biochemistry 2

Fall semester of 2017/2018 academic year

Head of Deparment of Medical Biochemistry: Prof. Tretter, László

Subject title: Faculty
Code: Credit:
Medical biochemistry 2 Medicine AOKOBI463_2A 5

 

  • Teaching secretary: Dr. István Léránt +36-1-459 1500#60034; +36-20-663 2267
  • Students Affairs Secretary: Mr. Zsolt Ozsváth EOK Building, 1st Floor, Passage ‘C’; +36-1-459 1500#60061