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Biochem 3 (MED)

Medical Biochemistry 3 

Lectures

Lectures: 

  • Tuesday 14:30-15:40 Szent-Györgyi Albert lecture hall
  • Thursday 09:50-11:00 Szent-Györgyi Albert lecture hall
Week Date  
01 2018.02.06 Metabolism of red blood cells. Red blood cell enzymopathies
  2018.02.08 Reseach Students’ Conference
02 2018.02.13 Metabolism of muscle and heart
  2018.02.15 Metabolic characteristics of brain and adipose tissue. Metabolism of lymphocytes and intestinal epithel cells
03 2018.02.20 The starving-feed cyclus and its regulation. Regulattion of hepatocyte metabolism in starvation
  2018.02.22 ChREBP signal transduction. The role of the SREBP, mTOR and PPAR system in the regulation of metabolism
 04 2018.02.27 AMP kinase, PGC1-a, HIF, p53. The role of thyroid hormones 
  2018.03.01 Na+,K+ ATP-ase. The permeability of cell membranes, P-type ATP-ase. Structure of Na+,K+ ATP-ase, Na+,K+ ATP-ase isoforms. Regulation. Secondary active transports. Na-H exchange 
05 2018.03.06 Chemical neurotransmission. Cholinergic neurotransmission. Biosynthesis of acetylcholine. receptors, acetylcholine esterase. Molecular mechanism of exocytosis
  2018.03.08 Noradrenerg neurotransmission. Synthesis and metabolism of norepinephrine. Synaptic uptake. Adrenerg receptors. Molecular mechanism of epinephrine and norepinephrine on various organs
06 2018.03.13 Dopaminergic and serotoninergic neurotransmission. Synthesis, transporteres, receptors. Biochemistry of Parkinson disease
  2018.03.15 1848 Revolution Memorial Day
07 2018.03.20 Glutamatergic neurotransmission
  2018.03.22 NO: Regulatory role of NO. Nitric oxide synthase. Guanylate cyclase. Molecular effects of nitric oxide
    Spring holiday: Good Friday, Easter Monday
08  2018.04.03 General properties of ion channels. Methods for studying ion channels. Molecular mechanisms of gating and permeation. Structure of K+ channels. (LCs)
  2018.04.05

Molecular diversity of ion channels. Voltage-gated K+ channels. ATP-sensitive K+ channels. Voltage-gated Cl- channels. The CFTR chloride channel. The nicotinic Acetylcholine Receptor. (LCS)

09 2018.04.10 General overview of blood clot formation and elimination. Fibrinogen and fibrin. Prothrombin activation and regulation of thrombin activity. Triggers of blood clotting, amplification of the initiation. (KK)
  2018.04.12 Inhibitors  of blood coagulation and  negative feedback mechanisms  (KK)
10 2018.04.17 Fibrinolysis. Activation of plasminogen. Inhibitors of plasmin  (KK)
  2018.04.19 Cellular elements of the haemostatic system. Platelets and von Willebrand factor  (KK)
11 2018.04.23 Neutrophils and endothelial cells in haemostasis.  (KK) (17:30-18:40 Szent-Györgyi Albert hall)
  2018.04.24 Faculty Day
  2018.04.26 Haemodynamical and biochemical interactions in haemostasis  (KK)
12 2018.05.01 May Day
  2018.05.03 The role of endothelial dysfunction in atherosclerosis. LDL oxidation and   pattern-recognition receptors (TLR, scavenger receptors). Cholesterol induced pyroptosis   (KK)
13 2018.05.08 Effect of cholesterol on  atherosclerotic  plaque formation. Risk factors of atherosclerosis related to cholesterol homeostasis (diabetes, hypertriglyceridemia). Biochemical background of atherosclerosis, prevention)
  2018.05.10 Signaltransduction-1: Therapeutic targeting of signal transduction pathways (TB)
14 2018.05.15 Signaltransduction-2: Cytokine signaling. Jak-STAT pathway. Calcium signaling. Nuclear receptors. (TB)
  2018.05.17 Signaltransduction-3: Wnt signal transduction pathways. Frizzled/Arrow/LRP receptors, Dsh, axin, APC proteins, GSK3, CK1α protein kinases, protein phosphatases (PP2A) and the ubiquitin system. Notch receptor signaling (TB)

Groups

Laboratory and seminar lessons in spring semester of the 2017/2018 academic year

Tuesday 10:00-12:10 EM03 Csala, Miklós prof
Tuesday 10:00-12:10 EM05 Bartha, Katalin dr
Tuesday 10:00-12:10 EM09 Tóth, Erzsébet dr
Tuesday 10:00-12:10 EM12 Mészáros, Tamás dr
Wednesday 08:00-10:10 EM04 Törőcsik, Beáta dr
Thursday 11:10-13:20 EM06 Komáry, Zsófia
Thursday 11:10-13:20 EM07 Margittai, Éva dr
Thursday 11:10-13:20 EM08 Kolev, Kraszimir prof
Thursday 11:10-13:20 EM10 Chinopoulos, Christos dr
Thursday 11:10-13:20 EM13 Komorowicz, Erzsébet
Thursday 13:50-16:00 EM01 Bak, Judit / Horváth, Gergő
Thursday 13:50-16:00 EM02 Müllner, Nándor
Thursday 13:50-16:00 EM14 Dóczy, Judit dr
Thursday 13:50-16:00 EM11 Kolev. Kraszimir prof
Thursday 13:50-16:00 EM15 Léránt, István / Törőcsik, Beáta

Laboratory lessons

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

Week    
01 2018.02.05_09 Metabolism of excercise (seminar)
02 2018.02.12_16 The isoenzyme profile of lactate-dehydrogenase (laboratory lesson)
03 2018.02.19_23 Acute and chronic liver disease (seminar)
04 2018.02.26_03.02 Determination of transaminase enzyme activity. Determination of serum creatine kinase activity (laboratory lesson)
05 2018.03.05_09 Extracellular matrix (seminar)
06 2018.03.10, 12-14 Metabolism of tumors (seminar)
07 2018.03.19_23 Determination of blood glucose level; determination of glycosylated haemoglobin (laboratory lessons)
  2018.03.26_04.02 Spring holiday + Eastern Monday
08 2018.04.03_06 The K+, Na+ transport ATP-ase (laboratory lesson) 
09 2018.04.09_13 Metabolism and human nervous system (seminar) 
10 2018.04.16_20 Investigation of microsomal drug mebatolism (laboratory lesson)
11 2018.04.23_27 Haemostatic abnormalities (seminar) 
12 2018.05.02_04 Energetics of living organism (seminar)
13 2018.05.07_11 Experimental models of blood coagulation (laboratory lesson)
14 2018.05.14_18 Research of specific literature of Biochemistry. Presentation of research at our department (Consultation)

 

Recommended books

  • Harper’s Illustrated Biochemistry (30th edition)
  • Powerpoint files of lectures 
  • Consultation manual 
  • Students’ own notes
  • Ask your laboratory teacher for the username and password of our authorized pages

Midterm exams

Midterm_2A 2018.04.26 17:30_18:50 EM06, ED01, ED02, ED03, ED04, FMMed, FMDen, EM15, EM03, EM12
Midterm_2B 2018.04.26 19:00_20:20 EM 01, 02,  04, 05, 07, 08, 09, 10, 11,  13, 14

ME=midterm exam; RE=retake exam; W=week; SzALH Szent-Györgyi Albert Lecture Hall; OR=oral retake of the 1st and 2nd midterm exam; LR=Laboratory rooms of Dept of Med Biochem

 

1st ME W06 2018.03.12 17:30-18:50 SzALH
    2018.03.12 19:00-20:20 SzALH
1st RE W07 2018.03.19 17:30-18:50 SzALH
    (2018.03.19) 19:00-20:20 SzALH
2nd ME W11 2018.04.26 17:30-18:50 SzALH
    2018.04.26 19:00-20:20 SzALH
2nd RE W13 2018.05.07 17:30-18:50 SzALH
    (2018.05.07) 19:00-20:20 SzALH
OR W14 2018.05.14 17:30- LR 
         

Midterm exam 1 (MED)

Midterm exam 2 (MED)

25 multiple choice type questions and 2 biochemistry problem sets (panels) are asked. Students may obtain 1 score for each correctly solved multiple choice questions. The both problem sets are evaluated by your own laboratory teachers (points: 0, 2, 3, 4, 5).  We calculate the sum of your scores and points of your midterm examinations and the tests are graded by the proposed limits of the table below:

Proposed limits for the marks of midterm are:

Sum of the grades and scores Grade of the midterm examination
0-18 1 (fail)
19-22 2 (pass)
23-26 3 (satisfactory)
27-30 4 (good)
31-35 5 (excellent)

The grade for the midterm exam is 1 (fail), if (i) the sum of the scores and the points is 18, or less (ii) each of the problem sets are evaluated by 0.

Failed midterms might be retaken twice.

Students having failed the first retake might sit for the second retake in the 13th week of the semester. The second retake is an oral exam conducted by an examination committee. Students having failed the first retake of both midterms 1 and 2 will be examined in the material of both midterms at the same time.

Competition

Medical Biochemistry 3 competition is held on the 14th week:

May 14, 2018 at 17:30, Szent-Györgyi Albert lecture hall.

Material: lectures, seminars and laboratory lessons of the fall and spring semesters of 2017/2018 and spring semester of the 2016/2017 academic year
Test: biochemistry problems and structures (max. 30 + 10) + 70 multiple choice type questions
Students reaching at least 75 % will be exempted from the examination by mark 5
Other exemptions are not possible
Conditition: Only registered students may come.  Regular students of groups EM01-EM15 may register for the competition whose midterm exam 1 and 2 were graded by 3, 4 or 5. (FM students or students who registered for the (medical) biochemistry, molecular and cell biology III this semester the second or the third time may not register for the biochemistry competition).

 

Registration starts on the 5th of May, 2018. Registration is closed on the 11th of May …… of May

 

Topic list

Final examination

Course-outline: Medical Biochemistry 3

Spring semester of 2017/2018 academic year

Head of Deparment of Medical Biochemistry: Prof. Tretter, László

Subject title: Faculty
Code: Credit:
Medical biochemistry 3 Medicine AOKOBI463_3A 5

 

  • Teaching secretary: Dr. István Léránt +36-1-459 1500#60034; +36-20-663 2267
  • Students Affairs Secretary: Mr. Zsolt Ozsváth EOK Building, 1st Floor, Passage ‘C’; +36-1-459 1500#60061

e-Lectures, e-Laboratory lessons, e-Seminars