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Biochem 2 (MED)

Lectures

Lecturers:  Beáta Törőcsik MD, PhD (BT); István Léránt (IL); prof. Kraszimir Kolev MD, PhD, DSc (KK); József Mandl MD, PhD, DSc (JM); Erzsébet Komorowicz MD, PhD (EK)

     
Tuesday 14:40-15:50 Szent-Györgyi Albert lecture hall
Thursday 10:00-11:10 Szent-Györgyi Albert lecture hall
     
    Metabolism of carbohydrates
01 2017.09.12 Carbohydrates. Digestion and absorption of carbohydrates, cellular glucose uptake, glucose transporters  BT
  2017.09.14 Glycolysis BT
02 2017.09.19 Metabolism of fructose and galactose. Gluconeogenesis. Cori-cycle  BT
  2017.09.21 Regulation of glycolysis and gluconeogenesis. Oxidation of alcohol and carbohydrate metabolism BT
03 2017.09.26 Metabolism of glycogen. Mobilization of glycogen in liver and muscle BT
  2017.09.28 Blood glucose level and its regulation: hyperglycaemia. Insulin release, insulin receptors BT
04 2017.10.03 Biochemistry of diabetes mellitus (DM) type I and type II DM  BT
    Metabolism of lipids
  2017.10.05 Metabolism of lipids – overview. Absorption of lipids. Metabolism of chylomicrons IL
05 2017.10.10 Mobilization of fatty acids in adipose tissue, its regulation. Transport in circulation. Free fatty acids, VLDL, IDL IL
  2017.10.12 Oxidation of fatty acids, ketone bodies IL
06 2017.10.17 Synthesis of fatty acids IL
  2017.10.19 Biosynthesis of triacylglycerol, phospholipids, their regulation IL
07 2017.10.24 Metabolism of cholesterol, cholesterol transport in circulation KK
  2017.10.26 Biosynthesis and metabolism of the bile acids, the importance of bile acids in lipid digestion. Cholesterol uptake and release by cells KK
08 2017.10.31 Pathobiochemistry of atherosclerosis KK
    Biotransformation
  2017.11.02 Characterization and classification of reactions in biotransformation. Phase I and Phase II reations. Clinical significance of induction JM
09 2017.11.07 Role of biotransformation in drug metabolism and detoxification. Metabolism of ethanol and its pathobiochemical effects JM
    Amino acids
  2017.11.09 Nitrogen balance. Digestion of proteins. Function of proteases, their regulation. Absorption of amino acids, amino acid transporters IL
10 2017.11.14 Catabolism of amino acids. Elimination of ammonia, reactions of ornithine cycle. Its regulation IL
  2017.11.16 Catabolism of amino acids. Catabolism of carbonic skeleton IL
11 2017.11.21 Catabolism of amino acids. Catabolism of carbonic skeleton. Role of vitamins in amino acid metabolism IL
  2017.11.23 Biosynthesis of nonessential amino acids and other amino acid derivatives IL
    Metabolism of nucleotides; synthesis and degradation of heme
12 2017.11.28 Structure and function of nucleotides. The fate of diatary nucleotides. Formation and elimination of uric acid, its metabolic role in humans. Molecular basis of gout. KK
  2017.11.30 Synthesis and degradation of purine and pyrimidine nucleotides. Effects of cytostatic drugs on nucleotide metabolism. KK
13 2017.12.05 Biosynthesis and degradation of heme. Homeostasis of iron.  KK
    Steroid hormones, eicosanoids
  2017.12.07 Synthesis of steroidal hormones in adrenal cortex. Synthesis of glucocorticoids. Biochemical background of adrenal cortex layers. Synthesis of mineralocorticoids, its regulation, prereceptor specificity. Effect of cortisol, regulation of cortisol synthesis. Androgen production of adrenal cortex EK
14 2017.12.12 Synthesis of sex hormones. Ovarian cyclic hormone production. Biosynthesis of progesterone and estradiol in placenta. Synthesis of testosterone in testis, formation and importance of dihydrotestosterone EK
  2017.12.14 Eicosanoids: synthesis of prostaglandins, thromboxanes and leukotriens (cyclooxygenase and lipoxigense pathway) EK

Lab. lessons

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

 Week  MM.dd:dd  
01 09.11:15 Safety rulesSafety rules for work in the laboratory Priciples of bioenergetics (Seminar)
02 09.18:22 Competitive inhibition of succinate dehydrogenase (lab)
03 09.25:29 Lactic acidosis (Seminar)
04 10.01:06 Fructose intolerance & McArdle’s disease (Seminar)
05 10.09:13 Oxidative phosphorylation in mitochondria (lab)
06 10.16:20 Enzyme kinetics – computer simulation (lab)
07 10.24:30 Allosteric regulation of pyruvate kinase  ASSAY (PK) (lab)
08 11.31:03 Signaltransduction of insulin (Seminar)
09 11.06:10 Digestion of lipids, role of bile acidsSubstrate specificity of trypsin and chymotrypsin. (lab)
10 11.13:17 Lipoprotein lipase, & carnitine deficiency (Seminar)
11 11.20:24 Glutamate-dehydrogenase
12 11.27:01 Hereditary hyperammonemias. (Seminar)
13 12.04:08 Determination of serum cholesterol and triglyceride (lab)
14 12.11:15 Vitamin B12 deficiency, methylmalonic acidemia (Seminar)

Groups

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

         
Monday 08:00-10:10 EM09 Tóth, Erzsébet  
  08:00-10:10 EM10 Chinopoulos, Christos  
  08:00-10:10 EM11 Kolev, Kraszimir prof  
  08:00-10:10 EM12 Mészáros, Tamás  
Monday 10:45-12:55 EM07 Margittai, Éva  
  10:45-12:55 EM08 Kolev, Kraszimir prof  
Monday 13:10-15:20 EM03 Komorowicz, Erzsébet  
  13:10-15:20 EM04 Törőcsik, Beáta  
Wednesday 08:00-10:10 EM13 Komáry, Zsófia  
  08:00-10:10 EM14 Dóczi, Judit
 
  10:20-12:30 EM15 Léránt, István / Törőcsik, Beáta  
Friday 08:00-10:10 EM01 Bak, Judit / Horváth, Gergő  
Friday 08:00-10:10 EM02 Müllner, Nándor  
Friday 08:00-10:10 EM05 Bartha, Katalin  
Friday 08:00-10:10 EM06 Csala, Miklós prof  
         
Group Room Day Time Laboratory / seminar teacher
EM01   Friday 08:00-10:10 Bak, Judit / Horváth, Gergő
EM02   Friday  08:00-10:10  Müllner, Nándor
EM03   Monday 13:10-15:20 Komorowicz, Erzsébet
EM04   Monday 13:10-15:20 Törőcsik, Beáta
EM05   Friday 08:00-10:10 Bartha, Katalin
EM06   Friday 08:00-10:10 Csala, Miklós prof 
EM07   Monday 10:45-12:55 Margittai, Éva
EM08   Monday 10:45-12:55 Kolev, Kraszimir prof
EM09   Monday 08:00-10:10 Tóth, Erzsébet
EM10   Monday 08:00-10:10 Chinopoulos, Christos
EM11   Monday 08:00-10:10 Kolev, Kraszimir prof
EM12   Monday 08:00-10:10 Mészáros, Tamás
EM13   Wednesday 08:00-10:10 Komáry, Zsófia
EM14   Wednesday 08:00-10:10 Dóczi, Judit
EM15   Wednesday 10:20-12:30 Léránt, István / Törőcsik, Beáta
         

Recommended books

Midterm exam

  • Midterm examination 1: Week 7. Oct 25, 2017  Wednesday 16:30-17:50 & 18:00-19:20 EOK Szent-Györgyi Albert Hall – Midterm exam # 1 {Medical Biochemistry 2 (MED)
    • Midterm examination 1-retake: Week 9. Nov 08, 2017  Wednesday 16:30-17:50  EOK Szent-Györgyi Albert Hall 
  • Midterm examination 2: Week 11. Nov 22, 2017  Wednesday 16:30-17:50 & 18:00-19:20 EOK Szent-Györgyi Albert Hall
    • Midterm examination 2-retake: Week 12. Nov 29, 2017  Wednesday 16:30-17:50- EOK Szent-Györgyi Albert Hall 
  • Oral retake of failed midterms (1 and/or 2) Week 13, Dec 6, 2017 Wednesday 16:30-20:00 EOK Dept Biochem – Laboratory room 4, 5 and 3
  • Passing both midterms is a prerequisite to acknowledgement of the semester.

Requirements

Laboratory exam

Competition

   

Final examination

 
 

Exemption

DOWNLOADS

Subject matter: Medical Biochemistry 2

Fall semester of 2017/2018 academic year

Head of Deparment of Medical Biochemistry: Prof. Tretter, László

Subject title: Faculty
Code: Credit:
Medical biochemistry 2 Medicine AOKOBI463_2A 5

 

  • Teaching secretary: Dr. István Léránt +36-1-459 1500#60034; +36-20-663 2267
  • Students Affairs Secretary: Mr. Zsolt Ozsváth EOK Building, 1st Floor, Passage ‘C’; +36-1-459 1500#60061