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BIOCHEM 2 (DEN) 2018/2019

Lectures

Lecturers:  Beáta Törőcsik MD, PhD (BT); István Léránt (IL); prof. Kraszimir KolevMD, PhD, DSc (KK); József Mandl MD, PhD, DSc (JM); Erzsébet Komorowicz MD, PhD (EK)

     
Tuesday 15:35-16:45 Szent-Györgyi Albert lecture hall
Thursday 09:20-10:30

Szent-Györgyi Albert lecture hall

Week   Metabolism of carbohydrates
01 2018.09.11 Carbohydrates. Digestion and absorption of carbohydrates, cellular glucose uptake, glucose transporters  BT
  2018.09.13 Glycolysis BT
02 2018.09.18 Metabolism of fructose and galactose. Gluconeogenesis. Cori-cycle  BT
  2018.09.20 Regulation of glycolysis and gluconeogenesis. Oxidation of alcohol and carbohydrate metabolism BT
03 2018.09.25 Metabolism of glycogen. Mobilization of glycogen in liver and muscle BT
  2018.09.27 Blood glucose level and its regulation: hyperglycaemia. Insulin release, insulin receptors BT
04 2018.10.02 Biochemistry of diabetes mellitus (DM) type I and type II DM  BT
    Biotransformation
  2018.10.04 Characterization and classification of reactions in biotransformation. Phase I and Phase II reations. Clinical significance of induction JM
05 2018.10.09 Role of biotransformation in drug metabolism and detoxification. Metabolism of ethanol and its pathobiochemical effects JM
    Metabolism of lipids
  2018.10.11 Metabolism of lipids – overview. Absorption of lipids. Metabolism of chylomicrons.  (IL)
06 2018.10.16 Mobilization of fatty acids in adipose tissue, its regulation. Transport on circulation. Free fatty acids, VLDL, IDL (IL)
  2018.10.18 Oxidation of fatty acids. Ketone bodies. (IL) 
07 2018.10.24 Synthesis of fatty acids (IL) (Wednesday 16:30-17:40)
    Amino acids
  2018.10.25 Biosynthesis of triacylglycerol, phospholipids, their regulation (IL) 
08 2018.10.30 Nitrogen balance. Digestion of proteins. Function of proteases, their regulation. Absorption of amino acids, amino acid transporters (IL) 
09 2018.11.06 Catabolism of amino acids. Elimination of ammonia, reactions of ornithine cycle. Its regulation (IL) 
  2018.11.07 Catabolism of amino acids. Catabolism of carbonic skeleton (IL) (Wednesday 16:30-17:40)
  2018.11.08 Catabolism of amino acids. Catabolism of carbonic skeleton. Role of vitamins in amino acid metabolism (IL) 
10 2018.11.13 Biosynthesis of nonessential amino acids and other amino acid derivatives (IL) 
    Metabolism of nucleotides; synthesis and degradation of heme
  2018.11.15 Structure and function of nucleotides. The fate of diatary nucleotides. Formation and elimination of uric acid, its metabolic role in humans. Molecular basis of gout. KK
11 2018.11.20 Synthesis and degradation of purine and pyrimidine nucleotides. Effects of cytostatic drugs on nucleotide metabolism. KK
  2018.11.22 Biosynthesis and degradation of heme. Homeostasis of iron.  KK
    Metabolism of cholesterol, cholesterol transport in circulation
12 2018.11.27 Metabolism of cholesterol, cholesterol transport in circulation KK
  2018.11.29 Biosynthesis and metabolism of the bile acids, the importance of bile acids in lipid digestion. Cholesterol uptake and release by cells KK
13 2018.12.04 Pathobiochemistry of atherosclerosis KK
    Steroid hormones and eicosanoids
  2018.12.06 Synthesis of steroidal hormones in adrenal cortex. Synthesis of glucocorticoids. Biochemical background of adrenal cortex layers. Synthesis of mineralocorticoids, its regulation, prereceptor specificity. Effect of cortisol, regulation of cortisol synthesis. Androgen production of adrenal cortex EK
14 2018.12.11 Synthesis of sex hormones. Ovarian cyclic hormone production. Biosynthesis of progesterone and estradiol in placenta. Synthesis of testosterone in testis, formation and importance of dihydrotestosterone EK
  2018.12.13 Eicosanoids: synthesis of prostaglandins, thromboxanes and leukotriens (cyclooxygenase and lipoxigense pathway) EK

Laboratory lessons / Seminars - regular students

01 09.10-09.14 ED1,3,5 Safety rules. Bioenergetics, mitochondrial metabolism (S)
02 09.17 09.21  ED2,4,6 Safety rules. Bioenergetics, mitochondrial metabolism (S)
03 09.24:09.28  ED1,3,5 Lactic acidosis (S)
04 10.01 10.05  ED2,4,6 Lactic acidosis,  (S)
05 10.08 10.12  ED1,3,5 Allosteric regulation of pyruvate kinase (P)
06 10.15 10.19  ED2,4,6 Allosteric regulation of pyruvate kinase (P)
07 10.24 10.26  ED1,3,5 Signaltransduction of insulin (S)
08 10.29 10.31  ED2,4,6 Signaltransduction of insulin (S)
09 11.05 11.09  ED1,3,5 Disorders of lipid metabolism (S)
10 11.12 11.26  ED2,4,6 Disorders of lipid metabolism (S)
11 11.19 11.23  ED1,3,5 Determination of serum cholesterol and triglycerides (P)
12 11.26 11.30  ED2,4,6 Determination of serum cholesterol and triglycerides (P)
13 12.03 12.07  ED1,3,5 Vitamin B12 and Folic acid, Iron homeostasis (S)
14 12.10 12.14  ED2,4,6 Vitamin B12 and Folic acid (S)

Groups

ED01 Thursday 10:50-13:20 Vér, Ágota dr
ED02 Thursday 10:50-13:20 Vér, Ágota dr
ED03 Thursday 10:50-13:20 Végh, Miklós dr
ED04 Thursday 10:50-13:20 Végh, Miklós dr
ED05 Monday 08:00-10:30 Bak, Judit dr
ED06 Monday 08:00-10:30 Bak, Judit dr

Laboratory lessons and seminars are held at laboratory rooms of the Department (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

Midterm exams

ME#1-Retake Oct 31 16:45-18:05  
  • Midterm examination 1: Week 6. Oct 17, 2018  Wednesday 16:45-18:05 & 18:15-19:30 EOK Szent-Györgyi Albert Hall
  • Midterm examination 1-retake: Week 8. Oct 31, 2018  Wednesday 16:45-18:05  EOK Szent-Györgyi Albert Hall 
  • Topic list –  first midterm exam
ME#1 Nov 28 16:45-18:05 ED groups, EM01-EM06
ME#1 Nov 28 18:15-19:30 EM07-EM15 + FM
  • Midterm examination 2: Week 12. Nov 28, 2018  Wednesday 16:45-18:05 & 18:15-19:30 EOK Szent-Györgyi Albert Hall 
  • Midterm examination 2-retake: Week 13. Dec 05, 2018  Wednesday 16:45-18:05  EOK Szent-Györgyi Albert Hall 
  • Topic list  – second midterm exam

Competition

Date: Dec 12, 2018, 16:45 EOK-Building, Szent-Györgyi Albert Lecture Hall
Material: lectures, seminars and laboratory lessons of the fall semesters of 2018/2019 academic year.

Students reaching at least 75 % will be exempted from the examination by mark 5. Other exemptions are not possible.

Conditition: 

  • grades 3 or better  at both midterms
  • registration for the subject matter of Dental Biochemistry 2 in the fall semester of 2018/2019 academic year
  • registration for the subject matter of Dental Biochemistry 1 in the spring semester of 2017/2018 academic year

Registration: starts on the 1 Dec, 2018. Registration is closed on the 7th of December, 2018

Recommended books

  • Harper’s Illustrated Biochemistry (30th edition)
  • Powerpoint files of lectures
  • Consultation manual 
  • Students’ own note

Requirements

DOWNLOADS

Subject matter: Dental Biochemistry 2

  • Fall semester of 2018/2019 academic year
  • Head of Deparment of Medical Biochemistry: Prof. Tretter, László
  • Subject title: Dental Biochemistry 2 Faculty: Dentistry
  • Code: FOKOOBI204_2A Credit: 4 Lec.: 3 Lab.: 1,5
  • Teaching secretary: Dr. István Léránt +36-1-459 1500#60034; +36-20-663 2267
  • Students Affairs Secretary: Mr. Zsolt Ozsváth EOK Building, 1st Floor, Passage ‘C’; +36-1-459 1500#60061

Laboratory lessons / Seminars - old curriculum

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

To sit for laboratory and seminar lessons of old curriculum, please, register for the medical groups (EM01-EM15) on Neptun!

1. 09.10_09.14 Safety rules for work in the laboratory . Amidolytic activity of trypsin (Pr)
2. 09.17_09.21 Competitive inhibition of succinate dehydrogenase  (Pr)
3. 09.24_09.28 Lactic acidosis (S) . Enzyme kinetics – computer simulation (S)
4. 10.01_10.05 Lactic acidosis (S). Enzyme kinetics – computer simulation  (S)
5. 10.08_10.12 Allosteric regulation of pyruvate kinase (Pr)
  10.13 SAT For groups: EM03, 05, 07, 13, 14, 15: Insulin signaltransduction  (S)
6. 10.15_10.19 Fructose intolerance (S), McArdle’s disease  (S)
7. 10.24_10.26 Oxidative phosphorylation in mitochondria (Pr)
8. 10.29_MON For groups: EM03, 05, 07, 13, 14, 15: Oxidative phosphorylation in mitochondria (Pr)
  10.30_10.31 Insulin signaltransduction  (S)
9. 11.05_11.09 Digestion of lipids (Pr) Substrate specificity of trypsin and chymotrypsin (Pr)
  11.10 SAT For groups EM 01, 08, 09, 11: Insulin signaltransduction  (S)
10. 11.12_11.16 Lipoprotein lipase (S); Carnitine deficiency  (S)
11. 11.19_11.23 Determination of serum cholesterol and triglyceride (Pr)
12 11.26_11.30 Hereditary hyperammonaemia (S)
13. 12.03_12.07 Glutamate dehydrogenase (Pr)
14. 12.10_12.14 Vit B12 deficiency (S); methylmalonic acidaemia .(S)