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Biochem 2 (DEN)

Lectures

Thursday 08:00-09:10 Szent-Györgyi Albert Lecture Hall
Friday 14:20-15:30 Hevesy György Lecture Hall

Semmelweis University Budapest IX., Tűzoltó utca 37-47 H-1094

Lecturers: László Tretter MD, PhD, DSc (LT), József Mandl MD, PhD, DSc, Member of the Hungarian Academy of Sciences (JM), Mária Sasvári MD, PhD, DSc (MS),, Kraszimir Kolev MD, PhD, DSc (KK), Miklós Csala MD, PhD, DSc (MCs), Erzsébet Komorowicz MD, PhD

e-lectures, e-laboratory lessons, e-seminars

This page is under constuction.

    Bioenergetics, metabolism of carbohydrates
01 2017.09.14 Glycolysis (MCs)
  2017.09.15 Formation of acetyl-CoA – pyruvate-dehydrogenase (MCs)
02 2017.09.21 Citrate cycle (MCs)
  2017.09.22 Gluconeogenesis. Glycogen metabolism (JM)
03 2017.09.28 Regulation of glycolysis and gluconeogenesis. (JM)
  2017.09.29 Regulation of glycogen metabolism. (JM)
04 2017.10.05 Regulation of blood glucose level. (JM)
  2017.10.06 Diabetes mellitus (JM)
05 2017.10.12 Degradation and synthesis of various carbohydrates. (JM)
    Metabolism of lipids, steroid hormones, eicosanoides
  2017.10.13 Metabolism of lipids – overview. Absorption of lipids. (BT)
06 2017.10.19 Oxidation of fatty acids, ketone bodies. (BT)
  2017.10.20 Synthesis of fatty acids. (BT)
07  2017.10.26 Lipoprotein metabolism. (BT)
  2017.10.27 Cholesterol homeostasis: sources of cholesterol in the cell, absorption of dietary cholesterol and inter-organ transport of cholesterol. Disposal of cholesterol and the role of bile acids. (KK)
08 2017.11.02 Regulatory mechanisms in cholesterol homeostasis, metabolic receptors and their function in the liver, intestine and blood vessel wall. Biochemistry of atherosclerosis. (KK)
  2017.11.03 Biosynthesis of steroid hormones in the adrenal cortex. Effects of mineralocorticoids and glucocorticoids, regulation of their biosynthesis. Signal transduction of steroid hormone receptors, genomic and non-genomic actions of steroid hormones. Congenital adrenal hyperplasias. (EK)
09 2017.11.09 Biosynthesis of sexual hormones. Cyclic changes in the ovaries, the cooperation of granulosa and theca interna cells. Placental progesterone and estradiol synthesis. (EK)
  2017.11.10 Eicosanoids: prostaglandins, thromboxanes and leukotrienes. The cyclooxygenase and the lipoxygenase pathways. Effects of eicosanoids on: platelet aggregation, gastric mucosal protection, myometrial contractility, inflammation. (EK)
    Metabolism of amino acids
10 2017.11.16 Metabolism of amino acids: the fate of the amino group. (MS)
  2017.11.17 Metabolism of amino acid: the fate of the carbon sceleton. (MS)
11 2017.11.23 Biosynthesis of nonessential amino acids and other amino acid derivatives. (MS)
    Metabolims of nucleotides, porphyrins and bile pigments
  2017.11.24 Synthesis and catabolism of purine nucleotides. (MS) 
12 2017.11.30 Pyrimidine nucleotide metabolism. Synthesis of deoxyribonucleotides (MS)
  2017.12.01 Metabolism of porphyrins and bile pigments (MS)
    Integration of metabolism
13 2017.12.07 Metabolism of red blood cells. Red blood cell enzymopathies. (LT)
  2017.12.08 Metabolism of skeletal and cardiac muscle, the role of SREBP, PPAR alpha and beta, (LT)
14 2017.12.14 Intermediary metabolism of kidney, metabolism in kidney cortex and medulla. (LT)
  2017.12.15 Regulation of the well-fed state and starvation. (LT)
     

Lab. lessons & seminars

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

e-lectures, e-laboratory lessons, e-seminars

     
01 2017.09.12 Safety rules. Priciples of bioenergetics (Seminar)
02 2017.09.19 Competitive inhibition of succinate dehydrogenase(lab)
03 2017.09.26 Lactic acidosis (Seminar)
04 2017.10.03 Fructose intolerance & McArdle’s disease (Seminar)
05 2017.10.10 Oxidative phosphorylation in mitochondria (lab)
06 2017.10.17 Enzyme kinetics – computer simulation (lab)
07 2017.10.24 Allosteric regulation of pyruvate kinase ASSAY (PK) (lab)
08 2017.10.31 Signaltransduction of insulin (Seminar)
09 2017.11.07 Digestion of lipids, role of bile acidsSubstrate specificity of trypsin and chymotrypsin. (lab)
10 2017.11.14 Lipoprotein lipase, & carnitine deficiency (Seminar)
11 2017.11.21 Glutamate dehydrogenase
12 2017.11.28 Hereditary hyperammonemias. (Seminar)
13 2017.12.05 Determination of serum cholesterol and triglyceride (lab)
14 2017.12.12 Vitamin B12 deficiency, methylmalonic acidemia (Seminar)
     

Groups

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

Groups of dentistry students

Group Day Time Laboratory/seminar teacher
ED1 Tuesday 10:25_12:20 Vér,  Ágota dr
ED2 Tuesday 10:25_12:20 Léránt, István dr/Végh, Miklós dr
ED3 Tuesday 10:25_12:20 Farkas, Veronika
ED4 Tuesday 10:25_12:20 Bak, Judit  dr/  Horváth, Gergő dr

Recommended books

  • Harper’s Illustrated Biochemistry (30th edition)
  • Powerpoint files of lectures – www.biochemistry.sote.hu, English, For students, Biochemistry II, authorized pages (username and password can be obtained from lab teachers)
  • Consultation manual 
  • e-lectures, e-laboratory lessons, e-seminars
  • Students’ own note

Midterm exam

  • Oral retake of failed midterms (1 and/or 2) Week 13, Dec 6, 2017 Wednesday 16:30-19:30 EOK Dept Biochem – Laboratory room 4, 5 and 3
  • Midterm examination 2: Week 11. Nov 22, 2017  Wednesday 16:30-18:00 & 18:10-19:30 EOK EOK Békéssy György Hall – Midterm exam # 2 (DEN + AOKOBI290_2A)
    • Midterm examination 2-retake: Week 12. Nov 29, 2017  Wednesday16:30-18:00- EOK Békéssy György Hall
  • Midterm examination 1: Week 7. Oct 25, 2017  Wednesday 16:30-18:00 & 18:10-19:30 EOK Békéssy György Hall – Midterm exam # 1 (DEN + AOKOBI290_2A)
  • Midterm examination 1-retake: Week 9. Nov 08, 2017  Wednesday 16:30-18:00  EOK Békéssy György Hall
  • Passing both midterms is a prerequisite to acknowledgement of the semester.
 

e-lectures, e-laboratory lessons, e-seminars

Requirements

Competition

Date: Dec 13, 2017, 16:45 EOK-Building, Békéssy  Lecture Hall
Material: lectures, seminars and laboratory lessons of the fall semesters of 2017/2018 academic year.

Students reaching at least 75 % will be exempted from the examination by mark 5. Other exemptions are not possible.

Conditition: 

  • grades 3 or better  at both midterms (grade of midterm exams of Oct 25/Nov8, Nov 22/Nov 29)
  • registration for the subject matter of Medical Biochemistry II in the fall semester of 2017/2018 academic year
  • registration for the subject matter of Medical Biochemistry I in the spring semester of 2016/2017 academic year

Registration: starts on the 1 Dec, 2017. Registration is closed on the 8th of December, 2017

DOWNLOADS

Lab-exam

Biochemistry, molecular and cell biology II

Fall semester of 2017/2018 academic year

Head of Deparment of Medical Biochemistry: Prof. Tretter, László

Subject title: Faculty
Code: Credit:
Biochemistry, molecular and cell biology II Dentistry FOKOOBI159_2A 5

Intermediary metabolism
Bioenergetics: Glycolysis. Formation of acetyl-CoA – the pyruvate-dehydrogenase complex. Citrate cycle. Carbohydrate metabolism: Gluconeogenesis. Glycogen metabolism. Regulation of glycolysis and gluconeogenesis. Regulation of glycogen metabolism. Regulation of blood glucose level. Diabetes mellitus. Degradation and synthesis of various carbohydrates. Lipid metabolism: Metabolism of lipids – overview. Absorption of lipids. Oxidation of fatty acids, ketone bodies. Synthesis of fatty acids. Lipoprotein metabolism. Cholesterol homeostasis. Regulatory mechanisms in cholesterol homeostasis. Steroid hormones of adrenal cortex, sexual hormones. Signal transduction mechanism of steroid hormone receptors. Eicosanoid. prostaglandins, thromboxanes and leukotrienes.
Amino acid metabolism: Metabolism of amino acids: the fate of the amino group, the fate of the carbon skeleton. Biosynthesis of nonessential amino acids and other amino acid derivatives. Synthesis and catabolism of purine nucleotides. Metabolism of nucleotides: Pyrimidine nucleotide metabolism. Synthesis of deoxyribonucleotides. Metabolism of porphyrins and bile pigments. Metabolic interrelationships, the metabolism of individual tissues: Metabolism of red blood cells. Red blood cell enzymopathies. Metabolism of skeletal and cardiac muscle, the role of SREBP, PPAR alpha and beta, Intermediary metabolism of kidney, metabolism in kidney cortex and medulla. Regulation of the well-fed state and starvation.

  • Teaching secretary: Dr. István Léránt +36-1-459 1500#60034; +36-20-663 2267
  • Students Affairs Secretary: Mr. Zsolt Ozsváth EOK Building, 1st Floor, Passage ‘C’; +36-1-459 1500#60061