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Lectures – Med. biochemistry II

Location, time: Tuesday 16:20-17:30; Thursday 09:20-10:30 Szent-Györgyi Albert Lecture Hall, EOK-Builing, Semmelweis University Budapest IX., Tűzoltó utca 37-47 H-1094
Lecture slides

Lecturers:

László Tretter MD, PhD, DSc (LT), Veronika Ádám MD, PhD, DSc, Member of the Hungarian Academy of Sciences  (VÁ), József Mandl MD, PhD, DSc, Member of the Hungarian Academy of Sciences (JM), Mária Sasvári MD, PhD, DSc (MS),, Kraszimir Kolev MD, PhD, DSc (KK), Miklós Csala MD, PhD (MCs), Erzsébet Komorowicz MD, PhD

Week mm:dd Topic
01 09:08 Glycolysis. (MCs)
  09:10 Formation of acetyl-CoA – pyruvate dehydrogenase. (MCs)
02 09:15 Citrate cycle. (MCs)
  09:17 Gluconeogenesis. Glycogen metabolism. (JM)
03 09:22 Regulation of glycolysis and gluconeogenesis. (JM)
  09:24 Regulation of glycogen metabolism. (JM)
04 09:29 Regulation of blood glucose level. (JM)
  10:01 Diabetes mellitus. (JM)
05 10:06 Degradation and synthesis of various carbohydrates. (JM)
  10:08 Metabolism of lipids – overview. Absorption of lipids. (LT)
06 10:13 Oxidation of fatty acids, ketone bodies. (LT)
  10:15 Synthesis of fatty acids. (LT)
07 10:20 Lipoprotein metabolism. (LT)
08 10:27 Cholesterol homeostasis: sources of cholesterol in the cell, absorption of dietary cholesterol and inter-organ transport of cholesterol. Disposal of cholesterol and the role of bile acids. (KK)
  10:27 Regulatory mechanisms in cholesterol homeostasis, metabolic receptors and their function in the liver, intestine and blood vessel wall. Biochemistry of atherosclerosis. (KK) (17:40-18:50 Szent-Györgyi Albert lecture hall
  10:29 Biosynthesis of steroid hormones in the adrenal cortex. Effects of mineralocorticoids and glucocorticoids, regulation of their biosynthesis. Signal transduction of steroid hormone receptors, genomic  and non-genomic actions of steroid hormones. Congenital adrenal hyperplasias. (EK)
09 11:03 Biosynthesis of sexual hormones. Cyclic changes in the ovaries, the cooperation of granulosa and theca interna cells. Placental progesterone and estradiol synthesis. (EK)
  11:05 Eicosanoids: prostaglandins, thromboxanes and leukotrienes. The cyclooxygenase and the lipoxygenase pathways. Effects of eicosanoids on: platelet aggregation, gastric mucosal protection, myometrial contractility, inflammation. (EK)
10 11:10 Metabolism of amino acids: the fate of the amino group. (MS)
  11:12 Metabolism of amino acid: the fate of the carbon sceleton. (MS)
11 11:17 Biosynthesis of nonessential amino acids and other amino acid derivatives. (MS)
  11:19 Synthesis and catabolism of purine nucleotides. (MS)
12 11:24 Pyrimidine nucleotide metabolism. Synthesis of deoxyribonucleotides (MS)
  11:26 Metabolism of porphyrins and bile pigments (MS)
13 12:01 Metabolism of red blood cells. Red blood cell enzymopathies. (LT)
  12:03 Metabolism of skeletal and cardiac muscle, the role of SREBP, PPAR alpha and beta, (LT)
14 12:08 Intermediary metabolism of kidney, metabolism in kidney cortex and medulla. (LT)
  12:10 Regulation of the well-fed state and starvation. (LT)